E40: Inflammation-triggered glial plasticity via modulation of Sox10 in the enteric and peripheral ganglia
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2026
End date : 31.12.2028
Project details
Scientific Abstract
Inflammatory bowel diseases impair gut neuro-immune circuits. While gut-innervating neurons are vulnerable to inflammation, satellite glia offer protection. Emerging evidence links glial plasticity to SOX10, but its regulation in gut-innervating ganglia remains unclear. We will investigate cytokine-driven modulation of SOX10 in glia of the myenteric, superior mesenteric, and dorsal root ganglia to uncover mechanisms of inflammation-induced plasticity and neuro-immune adaptation in colitis.
