P195: On the role and consequence of LINE-1 retroelements in extracellular vesicles
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2026
End date : 31.12.2026
Project details
Scientific Abstract
LINE-1 retroelements (L1) are upregulated in many autoimmune diseases, including SLE. Although L1 replicates intracellularly, we found L1 RNA packaged in extracellular vesicles (EV) in sera from SLE patients. Since L1 nucleic acids can trigger inflammatory pathways, we hypothesize that L1-EVs impact pathogenesis and could be used as novel biomarker in patients. Also, we ask whether L1 can be mobilized via EVs, challenging the dogma of L1s as intracellular pathogen.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Professur für Antivirale Angeborene Immunität
