A079: The nuclear receptor TR4 regulates TGFbeta-induced fibroblast activation and tissue fibrosis

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.01.2021

End date : 30.06.2023

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Impaired Mitochondrial Transcription Factor A Expression Promotes Mitochondrial Damage to Drive Fibroblast Activation and Fibrosis in Systemic Sclerosis (2022) Zhou X, Trinh MT, TRAN MANH C, Gießl A, Bergmann C, Györfi AH, Schett G, Distler J Journal article TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy (2021) Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, et al. Journal article Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation (2021) Györfi AH, Matei AE, Fuchs M, Liang C, Rigau A, Hong X, Zhu H, et al. Journal article Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease (2021) Zhang Y, Shen L, Dreißigacker K, Zhu H, Trinh MT, Meng X, TRAN MANH C, et al. Journal article X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc) (2021) Bergmann C, Hallenberger L, Chenguiti Fakhouri S, Chenguiti Fakhouri S, Merlevede B, Brandt A, Dees C, et al. Journal article 68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre, pilot study (2021) Bergmann C, Distler J, Treutlein C, Tascilar K, Müller A, Atzinger A, Matei AE, et al. Journal article Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis (2020) Chakraborty D, Zhu H, Juengel A, Summa L, Li YN, Matei AE, Zhou X, et al. Journal article