A091: Interfering with persistence of Human T-cell leukemia virus type 1 by manipulating the accessory protein p8

FAU own research funding: EFI / IZKF / EAM ...


Start date : 16.03.2020

End date : 15.09.2022

Extension date: 15.03.2023

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HDAC inhibitors Panobinostat and Romidepsin enhance tax transcription in HTLV-1-infected cell lines and freshly isolated patients' T-cells (2022) Schnell A, Kohrt S, Aristodemou A, Taylor GP, Bangham CRM, Thoma-Kreß A Journal article Alternative NF-kappa B Signaling Discriminates Induction of the Tumor Marker Fascin by the Viral Oncoproteins Tax-1 and Tax-2 of Human T-Cell Leukemia Viruses (2022) Heym S, Mohr C, Engelbrecht HC, Fleckenstein B, Thoma-Kreß A Journal article Characterizing the interaction between the htlv-1 transactivator tax-1 with transcription elongation factor ell2 and its impact on viral transactivation (2021) Kohrt S, Strobel S, Mann M, Sticht H, Fleckenstein B, Thoma-Kreß A Journal article, Original article Latency reversing agents: Kick and kill of htlv-1? (2021) Schnell A, Kohrt S, Thoma-Kreß A Journal article, Review article A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells (2020) Millen S, Meretuk L, Göttlicher T, Schmitt S, Fleckenstein B, Thoma-Kreß A Journal article Transfer of htlv-1 p8 and gag to target t-cells depends on vasp, a novel interaction partner of p8 (2020) Donhauser N, Socher E, Millen S, Heym S, Sticht H, Thoma-Kreß A Journal article