E030: Th17 and beyond: immune-mediated neurotoxicity determines onset and progression in Parkinson’s disease

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.04.2020

End date : 30.09.2022

Extension date: 31.03.2023

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An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons (2022) Krach F, Stemick J, Börstler T, Weiss A, Lingos I, Reischl S, Meixner H, et al. Journal article Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression (2022) Schneider Y, Turan S, Koller A, Krumbiegel M, Farrell M, Plotz S, Winkler J, Xiang W Journal article Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons (2022) van den Hurk M, Lau S, Marchetto MC, Mertens J, Stern S, Corti O, Brice A, et al. Journal article Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients (2022) Stern S, Lau S, Manole A, Rosh I, Percia MM, Ben Ezer R, Shokhirev MN, et al. Journal article CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy (2022) Battis K, Florio JB, Mante M, Lana A, Naumann I, Gauer C, Lambrecht V, et al. Journal article The Gut–Immune–Brain Axis: An Important Route for Neuropsychiatric Morbidity in Inflammatory Bowel Disease (2022) Masanetz RK, Winkler J, Winner B, Günther C, Süß P Journal article, Review article Store-operated calcium entry is reduced in spastin-linked hereditary spastic paraplegia (2022) Winner B, Rizo Garza T, Gebhardt L, Riedlberger J, Eberhardt E, Fester L, Alansary D, et al. Other publication type The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis (2022) Leupold L, Sigutova V, Gerasimova E, Regensburger M, Zundler S, Zunke F, Xiang W, et al. Journal article, Original article Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis (2022) Krach F, Wheeler EC, Regensburger M, Börstler T, Wend H, Vu AQ, Wang R, et al. Journal article, Original article Life style and Parkinson's disease (2022) Reichmann H, Csoti I, Koschel J, Lorenzl S, Schrader C, Winkler J, Wuellner U Journal article, Review article
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