IZKF-J71 (M4): Inhibition of the purinergic receptor P2Y2R as a potential therapeutic intervention in ADPKD

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.01.2019

End date : 30.06.2021

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Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo (2020) Cabrita I, Kraus A, Scholz JK, Skoczynski K, Schreiber R, Kunzelmann K, Buchholz B Journal article Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner (2020) Safi W, Kraus A, Grampp S, Schödel J, Buchholz B Journal article Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A (2019) Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K Journal article HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease (2018) Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, et al. Journal article