GENIUS dialysis: what comes next?: Plea for a flexible successor system GENIUS-Dialyse: Was kommt danach?: Plädoyer für ein flexibles Nachfolgesystem
Nusshag C, Enghard P, Schöffski O, Weinmann-Menke J (2026)
Publication Type: Journal article, Review article
Publication year: 2026
Journal
DOI: 10.1007/s11560-026-00947-6
Abstract
The GENIUS system occupies a unique functional position in acute dialysis. The mobile single-pass batch platform enables intermittent hemodialysis (IHD), sustained low-efficiency dialysis (SLED) and continuous veno-venous hemodialysis (CVVHD) for up to 24 h. The dialysate is centrally generated by reverse osmosis and filled into the system; no dialysis water supply, mobile reverse-osmosis unit or wastewater connection is required at the bedside. By discontinuation of the entire system, modality flexibility and a resource-sparing option with minimal bedside infrastructure are lost. Alternatives are traditional bag-based continuous veno-venous hemofiltration (CVVHDx) or conventional IHD/SLED, the latter requiring bedside water supply and wastewater disposal infrastructure. For 1500 treatment days, the modelling of the resource needs for CVVHDF resulted in 9.0-fold more packaging volume and generated 22.1-fold greater transport weight compared to the GENIUS system. As based on the current evidence continuous and prolonged modalities show comparable patient-relevant outcomes with respect to fixed endpoints, the gaps in treatment should be closed using a mobile successor platform with integrated regional citrate anticoagulation.
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Germany (DE)How to cite
APA:
Nusshag, C., Enghard, P., Schöffski, O., & Weinmann-Menke, J. (2026). GENIUS dialysis: what comes next?: Plea for a flexible successor system GENIUS-Dialyse: Was kommt danach?: Plädoyer für ein flexibles Nachfolgesystem. Die Nephrologie. https://doi.org/10.1007/s11560-026-00947-6
MLA:
Nusshag, Christian, et al. "GENIUS dialysis: what comes next?: Plea for a flexible successor system GENIUS-Dialyse: Was kommt danach?: Plädoyer für ein flexibles Nachfolgesystem." Die Nephrologie (2026).
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