Expanding the scope of PSMA-RLT: evaluating treatment in challenging mCRPC patients with poor performance status (ECOG 3)
Bastian MB, Wörl B, Blickle A, Burgard C, Speicher T, Bartholomä M, Schaefer-Schuler A, Maus S, Ezziddin S, Rosar F (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 52
Pages Range: 4893-4901
Journal Issue: 13
DOI: 10.1007/s00259-025-07346-4
Abstract
Purpose: Given the increasing inclusion of ECOG 3 patients in oncology practice, data on this subgroup in the context of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) remain limited. This study evaluates the safety and outcome of PSMA-RLT in metastatic castration-resistant prostate cancer (mCRPC) patients with ECOG performance status 3. Methods: In this analysis, a cohort of 18 mCRPC patients with ECOG performance status 3 who received PSMA-RLT was examined. The median number of treatment cycles was 2 (range: 1–10), with a mean cumulative administered activity of 21.5 ± 15.0 GBq (range: 2.7–62.6 GBq) of [177Lu]Lu-PSMA-617. Outcome and adverse events including hematologic and renal toxicities, fatigue, and xerostomia were analyzed. Results: 50% of patients achieved either stable disease or a partial biochemical response. Median progression-free survival and overall survival were 1.3 months and 2.8 months, respectively. Severe adverse events were uncommon, occurring in three patients: one developed grade 3 leukopenia, another experienced grade 3 thrombocytopenia, and one patient had pancytopenia of grade 3/4. No higher RLT-induced grade of renal toxicity and xerostomia were observed, whilst symptoms of fatigue improved in the cohort. Conclusion: This study indicates that PSMA-RLT is a feasible and overall well-tolerated treatment for mCRPC ECOG 3 patients with manageable toxicity profile. Despite limited survival outcomes, ECOG 3 status may be considered not to be a categorical exclusion criterion for RLT. Future prospective studies should further investigate the role of PSMA-RLT in this challenging subgroup.
Involved external institutions
Germany (DE)How to cite
APA:
Bastian, M.B., Wörl, B., Blickle, A., Burgard, C., Speicher, T., Bartholomä, M.,... Rosar, F. (2025). Expanding the scope of PSMA-RLT: evaluating treatment in challenging mCRPC patients with poor performance status (ECOG 3). European Journal of Nuclear Medicine and Molecular Imaging, 52(13), 4893-4901. https://doi.org/10.1007/s00259-025-07346-4
MLA:
Bastian, Moritz B., et al. "Expanding the scope of PSMA-RLT: evaluating treatment in challenging mCRPC patients with poor performance status (ECOG 3)." European Journal of Nuclear Medicine and Molecular Imaging 52.13 (2025): 4893-4901.
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