Site-Selective Functionalization of Cysteine Units in Peptides Through Meerwein Arylation Reactions Under Mild Conditions

Troeger D, Diesendorf N, Thurston R, Heinrich M (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Advanced Synthesis & Catalysis Wiley

Book Volume: 368

Article Number: e70594

Journal Issue: 12

DOI: 10.1002/adsc.70594

Abstract

α-Methylstyrenes are known as highly reactive scavengers for aryl radicals. By developing a novel bifunctional reagent, which combines a 2-bromoacyl unit for coupling to thiols with a styrene moiety for further functionalization via aryl radicals, a broadly applicable tool became available. Given that the two-step functionalizations can be carried out under particularly mild conditions, the novel methods also enable the selective modification of peptidic substrates at their cysteine units.

Authors with CRIS profile

Daniel Troeger Lehrstuhl für Pharmazeutische Chemie Nina Diesendorf Professur für Pharmazeutische Chemie Ryan Thurston Professur für Pharmazeutische Chemie Markus Heinrich Professur für Pharmazeutische Chemie

How to cite

APA:

Troeger, D., Diesendorf, N., Thurston, R., & Heinrich, M. (2026). Site-Selective Functionalization of Cysteine Units in Peptides Through Meerwein Arylation Reactions Under Mild Conditions. Advanced Synthesis & Catalysis, 368(12). https://doi.org/10.1002/adsc.70594

MLA:

Troeger, Daniel, et al. "Site-Selective Functionalization of Cysteine Units in Peptides Through Meerwein Arylation Reactions Under Mild Conditions." Advanced Synthesis & Catalysis 368.12 (2026).

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