Pain medicine aspects of the updated S2k guideline “Diagnosis and treatment of endometriosis” Schmerzmedizinische Aspekte in der aktualisierten S2k-Leitlinie „Diagnostik und Therapie der Endometriose“
Rosenberger DC, Erlenwein J, Häuser W, Pogatzki-Zahn E, Burghaus S (2026)
Publication Type: Journal article
Publication year: 2026
Journal
DOI: 10.1007/s00482-026-00950-9
Abstract
Background: The scheduled update of the S2k guideline “Diagnosis and treatment of endometriosis”, published by the Association of the Scientific Medical Societies in Germany (AWMF; registry number 015/045), was released on April 1, 2025. Methods: The guideline was developed under the coordination of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG), and the Swiss Society for Gynecology and Obstetrics (SGGG), together with 34 scientific societies (including the German Pain Society), professional organizations and associations, and three patient self-help groups. The systematic literature search followed a predefined algorithm and covered the period from 2019 to 2023. In a structured consensus process, 73 recommendations and 25 statements were formulated in accordance with AWMF regulations. Results: Compared to the 2020 guideline, the following changes were made regarding pain management: core therapeutic principles were expanded to include chapters on pharmacological symptomatic pain treatment, psychosomatic therapy, complementary therapy, and additional as well as multimodal treatment approaches. A tiered, multimodal treatment strategy for chronic endometriosis-related pain was recommended. Conclusion: The updated S2k guideline incorporates key concepts of pain medicine, including pain mechanisms (nociceptive, neuropathic, and nociplastic), risk factors for chronification, and biopsychosocial models. Recommendations for pharmacological and non-pharmacological interventions, including tiered multimodal treatment approaches, were developed and agreed upon in an interdisciplinary process based on current evidence and feasibility.
Authors with CRIS profile
Involved external institutions
Universitätsklinikum Münster
Germany (DE)
DRK Deutsches Schmerz-Zentrum Mainz / German Pain Center
Germany (DE)
Medizinisches Versorgungszentrum St. Johann GmbH Zentrum für Schmerztherapie
Germany (DE)
Germany (DE)
DRK Deutsches Schmerz-Zentrum Mainz / German Pain Center
Germany (DE)
Medizinisches Versorgungszentrum St. Johann GmbH Zentrum für Schmerztherapie
Germany (DE)
How to cite
APA:
Rosenberger, D.C., Erlenwein, J., Häuser, W., Pogatzki-Zahn, E., & Burghaus, S. (2026). Pain medicine aspects of the updated S2k guideline “Diagnosis and treatment of endometriosis” Schmerzmedizinische Aspekte in der aktualisierten S2k-Leitlinie „Diagnostik und Therapie der Endometriose“. Schmerz. https://doi.org/10.1007/s00482-026-00950-9
MLA:
Rosenberger, Daniela C., et al. "Pain medicine aspects of the updated S2k guideline “Diagnosis and treatment of endometriosis” Schmerzmedizinische Aspekte in der aktualisierten S2k-Leitlinie „Diagnostik und Therapie der Endometriose“." Schmerz (2026).
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