Multimodal imaging for quantifying atrophic lesions in pathologic myopia
Motloch K, Moukadem O, Goupillou P, Gaudric A, Couturier A, Philippakis E (2026)
Publication Type: Journal article
Publication year: 2026
Journal
DOI: 10.1038/s41433-026-04438-9
Abstract
Objectives: To assess the reliability and agreement of four imaging modalities in quantifying patchy atrophy in highly myopic (HM) eyes. Methods: Atrophy area was manually delineated by two independent graders and measured using an in-built feature with four imaging modalities: infrared imaging with OCT B-scan (IR + SD-OCT), blue-light fundus autofluorescence (BAF), ultra-wide-field (UWF) pseudocolor fundus photography (PCFP) and UWF green fundus autofluorescence (GAF). Intragrader, intergrader and interdevice agreements were then assessed. Results: Thirty-two eyes of 30 patients were included. The mean axial length was 30.31 ± 1.56 mm. From 128 analyzed images, the best intragrader repeatability was observed with IR + SD-OCT for both graders (ICC = 0.998 and 0.999), followed by BAF (ICC = 0.998 and 0.997), UWF PCFP (ICC = 0.992 and 0.999) and UWF GAF (ICC = 0.967 and 0.985). IR + SD-OCT was also superior in terms of intergrader repeatability (ICC = 0.999), followed by ICC = 0.998 for BAF, ICC = 0.996 for UWF PCFP, and ICC = 0.985 for UWF GAF. The atrophy areas measured using each device correlated (r = 0.958–0.995; all p < 0.001), but differed significantly (p < 0.001). PCFP and BAF measured respectively the smallest and largest median area (2.14 mm² [IQR: 3.88 mm²] and 2.90 mm² [IQR: 5.28 mm²], respectively). A larger lesion size was associated with greater interdevice disagreement. Conclusion: All imaging modalities provided reliable atrophy area measurements, which correlated but differed significantly. IR + SD-OCT showed the strongest agreement.
Involved external institutions
France (FR)How to cite
APA:
Motloch, K., Moukadem, O., Goupillou, P., Gaudric, A., Couturier, A., & Philippakis, E. (2026). Multimodal imaging for quantifying atrophic lesions in pathologic myopia. Eye. https://doi.org/10.1038/s41433-026-04438-9
MLA:
Motloch, Karolina, et al. "Multimodal imaging for quantifying atrophic lesions in pathologic myopia." Eye (2026).
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