Adhesion G protein-coupled receptors

Langenhan T, Anderson GR, Araç D, Aust G, Avila-Zozaya M, Bagger SM, Barth P, Berndt S, Blacklow SC, Blanco-Redondo B, Boucard AA, Bridges JP, Brodmerkel LS, Caron KM, Chung YK, Dates AN, de Araujo Farias V, Del Toro D, Duman JG, Engel F, Favara DM, Formstone CJ, Fu C, Garcia De Las Bayonas A, Georgiadi A, Gloriam DE, Hall RA, Hamann J, Hildebrand PW, Hsiao CC, Huang BX, Javitch JA, Kim HY, Kittel RJ, Kleinau G, Leduc R, Liebscher I, Lin HH, Linnert J, Ludwig MG, Martinelli DC, Mathiasen S, Matúš D, Melkumyan M, Moreno-Salinas AL, Mulder J, Nash MA, Pal K, Pederick DT, Perry-Hauser NA, Piao X, Ping YQ, Placantonakis DG, Pohl F, Prömel S, Rosenkilde MM, Sabbagh L, Sando RC, Scheerer P, Schöneberg T, Seiradake E, Selcho M, Seufert F, Singh A, Skiniotis G, Spiess K, Sträter N, Strutt D, Südhof TC, Sun J, Tall GG, Thor D, Tilley DG, Tolias KF, Vallon M, Van Meir EG, Vanhollebeke B, Wiggin GR, Wolfrum U, Yan J, Zaidman NA, Zou Y, Scholz N (2026)

Publication Type: Journal article, Review article

Publication year: 2026

Journal

Book Volume: 78

Article Number: 100116

Journal Issue: 3

DOI: 10.1016/j.pharmr.2026.100116

Abstract

Adhesion G protein–coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive assessment of the current understanding of aGPCR biology, including a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches, and model systems for their investigation, as well as emerging approaches for their therapeutic targeting. Significance Statement Adhesion G protein–coupled receptors are versatile cell-surface proteins that integrate structural, biochemical, and physiological functions, with major roles in health and disease. This review summarizes current knowledge of their molecular features, functions in diverse model systems, and emerging opportunities for therapeutic targeting, providing a comprehensive resource that connects basic biology with translational applications across multiple scientific disciplines.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Leipzig Germany (DE) University of California, Riverside (UCR) United States (USA) (US) University of Chicago United States (USA) (US) University of North Carolina at Chapel Hill United States (USA) (US) University of Copenhagen Denmark (DK) École Polytechnique Fédérale de Lausanne (EPFL) Switzerland (CH) National Polytechnic Institute of Mexico / Instituto Politécnico Nacional de México Mexico (MX) National Jewish Health United States (USA) (US) University of California San Francisco (UCSF) United States (USA) (US) University of Alabama at Birmingham (UAB) United States (USA) (US) Universitat de Barcelona (UB) / University of Barcelona Spain (ES) Baylor College of Medicine United States (USA) (US) MRC Laboratory of Molecular Biology Germany (DE) University of Hertfordshire United Kingdom (GB) National University of Singapore (NUS) Singapore (SG) University of California, Berkeley (UC Berkeley) United States (USA) (US) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra Netherlands (NL) National Institute on Alcohol Abuse and Alcoholism (NIAAA) United States (USA) (US) Columbia University Irving Medical Center (CUIMC) United States (USA) (US) Universität Leipzig Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Université de Sherbrooke Canada (CA) Harvard University United States (USA) (US) Emory University United States (USA) (US) Stanford University United States (USA) (US) Karolinska Institute Sweden (SE) Universität Basel Switzerland (CH) Ashoka University India (IN) Johns Hopkins Hospital United States (USA) (US) University of Glasgow United Kingdom (GB) Shandong First Medical University (Shandong Academy of Medical Sciences) China (CN) New York University (NYU) United States (USA) (US) Heinrich-Heine-Universität Düsseldorf Germany (DE) Vanderbilt University Medical Center United States (USA) (US) University of Oxford United Kingdom (GB) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE) Chang Gung University (CGU) / 長庚大學 Taiwan (TW) Novartis AG Switzerland (CH) University of Connecticut Health Center (UConn Health) United States (USA) (US) St. Jude Children’s Research Hospital United States (USA) (US) University of Sheffield United Kingdom (GB) Shandong-University (SDU) China (CN) University of Michigan United States (USA) (US) Temple University United States (USA) (US) Julius-Maximilians-Universität Würzburg Germany (DE) Université libre de Bruxelles (ULB) / Free University of Brussels Belgium (BE) Nxera Pharma UK Limited United Kingdom (GB) University of New Mexico (UNM) / Universidad de Nuevo México United States (USA) (US)

How to cite

APA:

Langenhan, T., Anderson, G.R., Araç, D., Aust, G., Avila-Zozaya, M., Bagger, S.M.,... Scholz, N. (2026). Adhesion G protein-coupled receptors. Pharmacological Reviews, 78(3). https://doi.org/10.1016/j.pharmr.2026.100116

MLA:

Langenhan, Tobias, et al. "Adhesion G protein-coupled receptors." Pharmacological Reviews 78.3 (2026).

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