Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report

Manchia M, Adli M, Akula N, Ardau R, Aubry JM, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, Biernacka JM, Brichant-Petitjean C, Bui E, Calkin CV, Cheng ATA, Chillotti C, Cichon S, Clark S, Czerski PM, Dantas C, Del Zompo M, DePaulo JR, Detera-Wadleigh SD, Etain B, Falkai P, Frisén L, Frye MA, Fullerton J, Gard S, Garnham J, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hoban R, Hou L, Jamain S, Kahn JP, Kassem L, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Kuo PH, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell PB, Mondimore F, Monteleone P, Nallet A, Neuner M, Novák T, O'Donovan C, Ösby U, Ozaki N, Perlis RH, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert OK, Schweizer B, Seemüller F, Grigoroiu-Serbanescu M, Severino G, Seymour LR, Slaney C, Smoller JW, Squassina A, Stamm T, Steele J, Stopkova P, Tighe SK, Tortorella A, Turecki G, Wray NR, Wright A, Zandi PP, Zilles D, Bauer M, Rietschel M, McMahon FJ, Schulze TG, Alda M (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Book Volume: 8

Article Number: e65636

Journal Issue: 6

DOI: 10.1371/journal.pone.0065636

Abstract

Objective:The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen) study.Materials and Methods:Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling.Results:Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders).Conclusions:We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.

Involved external institutions

Julius-Maximilians-Universität Würzburg Germany (DE) Poznan University of Medical Sciences / Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu Poland (PL) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Georg-August-Universität Göttingen Germany (DE) Universidade Estadual de Campinas (UNICAMP) / University of Campinas Brazil (BR) Medizinische Universität Graz Austria (AT) Charité - Universitätsmedizin Berlin Germany (DE) National Institute of Mental Health Information Resource Center United States (USA) (US) Johns Hopkins Hospital United States (USA) (US) Mood Disorders Ottawa Canada (CA) Università degli Studi di Napoli Federico II Italy (IT) Douglas Research Centre / Le Centre de Recherche Douglas Canada (CA) University of Queensland Australia (AU) University of New South Wales (UNSW) Australia (AU) Johns Hopkins University (JHU) United States (USA) (US) Technische Universität Dresden Germany (DE) Universitätsklinikum Mannheim / University Medical Centre Mannheim (Universitätsmedizin Mannheim) Germany (DE) Dalhousie University Canada (CA) Institut Mondor de Recherche Biomédicale France (FR) Centre Hospitalier Régional et Universitaire de Nancy (CHRU de Nancy / CHU de Nancy) France (FR) National Institute of Mental Health (NIMH) / Národní ústav duševního zdraví (NUDZ) Czech Republic (CZ) University of Adelaide Australia (AU) RIKEN Center for Brain Science (CBS) Japan (JP) Academia Sinica / 中央研究院 Taiwan (TW) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) Fujita Health University Japan (JP) Azienda Ospedaliera Universitaria di Cagliari Italy (IT) Massachusetts General Hospital United States (USA) (US) Université de Montréal Canada (CA) Università degli Studi di Cagliari Italy (IT) National Taiwan University (NTU) Taiwan (TW) Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG) Switzerland (CH) Karolinska Institute Sweden (SE) Universidad de Antioquía (UDEA) Colombia (CO) Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal France (FR) Mayo Clinic United States (USA) (US) Neuroscience Research Australia NeuRA Australia (AU) Klinikum der Universität München (LMU Klinikum) Germany (DE) "Prof. Dr. Alexandru Obregia" Clinical Hospital of Psychiatry / Spitalul Clinic de Psihiatrie Prof. Dr. Alexandru Obregia Romania (RO) Centre Hospitalier Charles Perrens (CHCP) France (FR)

How to cite

APA:

Manchia, M., Adli, M., Akula, N., Ardau, R., Aubry, J.M., Backlund, L.,... Alda, M. (2013). Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS ONE, 8(6). https://doi.org/10.1371/journal.pone.0065636

MLA:

Manchia, Mirko, et al. "Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report." PLoS ONE 8.6 (2013).

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