Lithium-induced Clock Gene Expression in Lymphoblastoid Cells of Bipolar Affective Patients
Kittel-Schneider S, Schreck S, Ziegler C, Weiflog L, Hilscher M, Schwarz R, Schnetzler L, Neuner M, Reif A (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 48
Pages Range: 145-149
Journal Issue: 4-5
Abstract
Introduction: Disturbances of circadian rhythms occur in all episodes of bipolar disorder (BD). Lithium, as gold-standard in the maintenance treatment of BD, is known to influence circadian processes. Methods: In a pilot study lymphoblastoid cell lines (LCLs) were generated from 8 BD patients and 6 healthy controls. The LCLs were treated with lithiumchloride (LiCl) for 3 weeks. Cell cycles were then synchronized and expressional analysis by quantitative Real Time PCR was done. Results: BD and controls differed in the period length regarding DBP (albumin D-box binding protein) expression and DBP expression was also influenced by lithium treatment. Furthermore, baseline DBP expression was significantly different between non-treated BD and healthy controls. None of the other analyzed circadian genes showed to be influenced by chronic lithium treatment or to be differentially regulated due to the diagnosis. Discussion: We here show that chronic lithium treatment of LCLs leads to decreased expression of the clock gene DBP, rendering DBP a lithium-regulated gene. We could confirm the role of the circadian clock as well in lithium mode of action as in the pathomechanisms of BD although future studies with a greater number of participants and cell lines are needed.
Involved external institutions
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Bezirkskrankenhaus Lohr / Krankenhaus für Psychiatrie, Psychotherapie und Psychosomatische Medizin
Germany (DE)
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Bezirkskrankenhaus Lohr / Krankenhaus für Psychiatrie, Psychotherapie und Psychosomatische Medizin
Germany (DE)
How to cite
APA:
Kittel-Schneider, S., Schreck, S., Ziegler, C., Weiflog, L., Hilscher, M., Schwarz, R.,... Reif, A. (2015). Lithium-induced Clock Gene Expression in Lymphoblastoid Cells of Bipolar Affective Patients. Pharmacopsychiatry, 48(4-5), 145-149. https://doi.org/10.1055/s-0035-1549946
MLA:
Kittel-Schneider, S., et al. "Lithium-induced Clock Gene Expression in Lymphoblastoid Cells of Bipolar Affective Patients." Pharmacopsychiatry 48.4-5 (2015): 145-149.
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