Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder
Brevik EJ, van Donkelaar MM, Weber H, Sánchez-Mora C, Jacob C, Rivero O, Kittel-Schneider S, Garcia-Martínez I, Aebi M, van Hulzen K, Cormand B, Ramos-Quiroga JA, Lesch KP, Reif A, Ribasés M, Franke B, Posserud MB, Johansson S, Lundervold AJ, Haavik J, Zayats T (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 171
Pages Range: 733-747
Journal Issue: 5
DOI: 10.1002/ajmg.b.32434
Abstract
Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P < 5.00E-08). The strongest signal in aADHD was observed at rs10826548, within a long noncoding RNA gene (beta = −1.66, standard error (SE) = 0.34, P = 1.07E-06), closely followed by rs35974940 in the neurotrimin gene (beta = 3.23, SE = 0.67, P = 1.26E-06). The top GWA SNPs observed in aADHD showed significant enrichment of signals from both the defiant/vindictive dimension (Fisher's P-value = 2.28E-06) and the irritable dimension in cADHD (Fisher's P-value = 0.0061). In sum, our results identify a number of biologically interesting markers possibly underlying childhood aggressiveness and provide targets for further genetic exploration of aggressiveness across psychiatric disorders. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.
Involved external institutions
Haukeland University Hospital / Haukeland universitetssykehus
Norway (NO)
Donders Institute for Brain, Cognition and Behaviour
Netherlands (NL)
Goethe-Universität Frankfurt am Main
Germany (DE)
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Spain (ES)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Psychiatrische Universitätsklinik Zürich
Switzerland (CH)
Universitat de Barcelona (UB) / University of Barcelona
Spain (ES)
University of Bergen / Universitetet i Bergen
Norway (NO)
Norway (NO)
Donders Institute for Brain, Cognition and Behaviour
Netherlands (NL)
Goethe-Universität Frankfurt am Main
Germany (DE)
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Spain (ES)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Psychiatrische Universitätsklinik Zürich
Switzerland (CH)
Universitat de Barcelona (UB) / University of Barcelona
Spain (ES)
University of Bergen / Universitetet i Bergen
Norway (NO)
How to cite
APA:
Brevik, E.J., van Donkelaar, M.M., Weber, H., Sánchez-Mora, C., Jacob, C., Rivero, O.,... Zayats, T. (2016). Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 171(5), 733-747. https://doi.org/10.1002/ajmg.b.32434
MLA:
Brevik, Erlend J., et al. "Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder." American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 171.5 (2016): 733-747.
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