Promising Developments in the Use of Induced Pluripotent Stem Cells in Research of ADHD

Yde Ohki CM, McNeill RV, Nieberler M, Radtke F, Kittel-Schneider S, Grünblatt E (2022)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2022

Journal

Current Topics in Behavioral Neurosciences Springer Verlag

Publisher: Springer Science and Business Media Deutschland GmbH

Series: Current Topics in Behavioral Neurosciences

Book Volume: 57

Pages Range: 483-501

DOI: 10.1007/7854_2022_346

Abstract

Although research using animal models, peripheral and clinical biomarkers, multimodal neuroimaging techniques and (epi)genetic information has advanced our understanding of Attention-Deficit Hyperactivity Disorder (ADHD), the aetiopathology of this neurodevelopmental disorder has still not been elucidated. Moreover, as the primary affected tissue is the brain, access to samples is problematic. Alternative models are therefore required, facilitating cellular and molecular analysis. Recent developments in stem cell research have introduced the possibility to reprogram somatic cells from patients, in this case ADHD, and healthy controls back into their pluripotent state, meaning that they can then be differentiated into any cell or tissue type. The potential to translate patients’ somatic cells into stem cells, and thereafter to use 2- and 3-dimensional (2D and 3D) neuronal cells to model neurodevelopmental disorders and/or test novel drug therapeutics, is discussed in this chapter.

Involved external institutions

Psychiatrische Universitätsklinik Zürich CH Switzerland (CH) Universitätsklinikum Würzburg DE Germany (DE)

How to cite

APA:

Yde Ohki, C.M., McNeill, R.V., Nieberler, M., Radtke, F., Kittel-Schneider, S., & Grünblatt, E. (2022). Promising Developments in the Use of Induced Pluripotent Stem Cells in Research of ADHD. In (pp. 483-501). Springer Science and Business Media Deutschland GmbH.

MLA:

Yde Ohki, Cristine Marie, et al. "Promising Developments in the Use of Induced Pluripotent Stem Cells in Research of ADHD." Springer Science and Business Media Deutschland GmbH, 2022. 483-501.

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