Eckstein M (2025)
Publication Type: Journal article
Publication year: 2025
DOI: 10.1007/s00292-025-01496-w
Enfortumab vedotin (EV) is a targeted antibody-drug conjugate (ADC) directed against NECTIN4 and approved for treatment of metastatic urothelial carcinoma (mUC) after failure of platinum-based chemotherapy and immune checkpoint inhibitors. However, not all patients benefit equally from EV, highlighting the need for a predictive biomarker. In this multicenter study, 108 EV-treated mUC patients were analyzed for genomic NECTIN4 amplifications using fluorescence in situ hybridization (FISH). Approximately one-quarter of tumors showed NECTIN4 amplification, which was strongly associated with increased membranous protein expression and an objective response rate of 96%. Amplified tumors also had significantly prolonged overall survival. In a control cohort without EV, NECTIN4 amplification had no prognostic impact. These findings identify NECTIN4 amplification as a stable, predictive biomarker that may guide treatment decisions in mUC. Data from TCGA further suggest a cross-entity relevance of NECTIN4 amplification, supporting future clinical exploration of EV in other solid tumors.
APA:
Eckstein, M. (2025). NECTIN4 amplification as a predictive biomarker for enfortumab vedotin response NECTIN4-Amplifikation als prädiktiver Biomarker für das Ansprechen auf Enfortumab-Vedotin. Die Pathologie. https://doi.org/10.1007/s00292-025-01496-w
MLA:
Eckstein, Markus. "NECTIN4 amplification as a predictive biomarker for enfortumab vedotin response NECTIN4-Amplifikation als prädiktiver Biomarker für das Ansprechen auf Enfortumab-Vedotin." Die Pathologie (2025).
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