Optical Measurement of the Mass Density of Biological Samples
Möckel C, Li J, Zanini G, Guck J, Scarcelli G (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 12
Pages Range: 6368-6373
Journal Issue: 11
DOI: 10.1021/acsphotonics.5c01861
Abstract
Mass density is a vital property for the improved biophysical understanding of and within biological samples. It is increasingly attracting active investigations, but still lacks reliable, noncontact techniques to accurately characterize it in biological systems. Contrary to popular belief, refractive index information alone is insufficient to determine a sample’s mass density, as we demonstrate here theoretically and experimentally. Instead, we measured the nonlinear gain of stimulated Brillouin scattering to provide additional information for the mass density estimation. This all-optical method reduces the estimation error 10-fold, offering a more accurate and universal technique for mass density measurements.
Authors with CRIS profile
Involved external institutions
Max-Planck-Institut für die Physik des Lichts (MPL) / Max Planck Institute for the Science of Light
Germany (DE)
University of Maryland, College Park (UMD)
United States (USA) (US)
Germany (DE)
University of Maryland, College Park (UMD)
United States (USA) (US)
How to cite
APA:
Möckel, C., Li, J., Zanini, G., Guck, J., & Scarcelli, G. (2025). Optical Measurement of the Mass Density of Biological Samples. ACS Photonics, 12(11), 6368-6373. https://doi.org/10.1021/acsphotonics.5c01861
MLA:
Möckel, Conrad, et al. "Optical Measurement of the Mass Density of Biological Samples." ACS Photonics 12.11 (2025): 6368-6373.
BibTeX: Download