Dedifferentiated and Undifferentiated Melanoma

Iro AK, Agaimy A (2025)

Publication Type: Journal article, Review article

Publication year: 2025

Journal

Surgical Pathology Clinics Elsevier BV

DOI: 10.1016/j.path.2025.08.003

Abstract

Melanoma showing subclonal (dedifferentiated) or global (undifferentiated) loss of all routinely used immunophenotypic melanocytic markers has been the topic of several studies in recent years. These recent studies highlighted a significant underrecognition of this diagnostically challenging phenomenon and paved the way for appropriate systemic therapy utilizing established and emerging melanoma-tailored therapy protocols that should enable achievement of the highest therapy response rate and, hence, improve prognosis. This review summarizes these recent developments related to the topic.

Authors with CRIS profile

Abbas Agaimy Institute of Pathology

Involved external institutions

Klinikum Nürnberg DE Germany (DE)

How to cite

APA:

Iro, A.K., & Agaimy, A. (2025). Dedifferentiated and Undifferentiated Melanoma. Surgical Pathology Clinics. https://doi.org/10.1016/j.path.2025.08.003

MLA:

Iro, Ann Kristin, and Abbas Agaimy. "Dedifferentiated and Undifferentiated Melanoma." Surgical Pathology Clinics (2025).

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