Impact of endoscopy-based research on quality of life in healthy volunteers
Link A, Treiber G, Peters B, Wex T, Malfertheiner P (2010)
Publication Type: Journal article
Publication year: 2010
Journal
Book Volume: 16
Pages Range: 467-473
Journal Issue: 4
Abstract
AIM: To study the impact of an endoscopy-based long-term study on the quality of life in healthy volunteers (HV). METHODS: Ten HV were included into a long-term prospective endoscopy-based placebo-controlled trial with 15 endoscopic examinations per person in 5 different drug phases. Participants completed short form-36 (SF-36) and visual analog scale-based questionnaires (VAS) for different abdominal symptoms at days 0, 7 and 14 of each drug phase. Analyses were performed according to short- and long-term changes and compared to the control group. RESULTS: All HV completed the study with duration of more than 6 mo. Initial quality of life score was comparable to a general population. Analyses of the SF-36 questionnaires showed no significant changes in physical, mental and total scores, either in a short-term perspective due to different medications, or to potentially endoscopic procedure-associated long-term cumulative changes. Analogous to SF-36, VAS revealed no significant changes in total scores for pathological abdominal symptoms and remained unchanged over the time course and when compared to the control population. CONCLUSION: This study demonstrates that quality of life in HV is not significantly affected by a long-term endoscopy-based study with multiple endoscopic procedures. © 2010 Baishideng. All rights reserved.
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Germany (DE)How to cite
APA:
Link, A., Treiber, G., Peters, B., Wex, T., & Malfertheiner, P. (2010). Impact of endoscopy-based research on quality of life in healthy volunteers. World Journal of Gastroenterology, 16(4), 467-473. https://doi.org/10.3748/wjg.v16.i4.467
MLA:
Link, Alexander, et al. "Impact of endoscopy-based research on quality of life in healthy volunteers." World Journal of Gastroenterology 16.4 (2010): 467-473.
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