Prevalence of Helicobacter pylori infection among blood donors in Saxony-Anhalt, Germany - A region at intermediate risk for gastric cancer
Franck C, Hoffmann A, Link A, Schulz C, Wuttig K, Becker E, Heim M, Venerito M, Malfertheiner P (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 55
Pages Range: 653-656
Journal Issue: 7
Abstract
Background In the federal state of Saxony-Anhalt, gastric cancer (GC) incidence ranks among the highest in Germany. Helicobacter pylori prevalence is a surrogate marker for GC risk in a given population. In 2010 we reported an H. pylori seroprevalence of 44.4% in patients at the emergency ward of the University Hospital of Magdeburg, the capital of Saxony-Anhalt. Our aim is to update these findings in a cohort of healthy blood donors from the same region. Materials and methods The sera of 516 consecutive blood donors (40.1±14.1 years; 286 males and 230 females) were tested for antibodies against H. pylori and CagA. Data on demographics and previous H. pylori eradication therapy were obtained by means of a structured questionnaire. Blood donors with positive serology for H. pylori or CagA and/or history of eradication therapy were classified as H. pylori-positive. Results Overall, 28.9% of the study cohort were H. pylori-positive. The prevalence was higher in older generations (9% in 18-20 years up to 47% in 61-70 years). In 44.4% of H. pylori IgG-positive donors, CagA serology was also positive. This proportion was not age-dependent. Study participants with siblings were by trend more often H. pylori-positive (p=0.066). Conclusion Compared to our previous study in patients at the emergency ward, we found by trend lower age-related H. pylori prevalence rates. In our cohort of healthy blood donors, we confirmed a lower H. pylori prevalence in younger generations.
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Germany (DE)How to cite
APA:
Franck, C., Hoffmann, A., Link, A., Schulz, C., Wuttig, K., Becker, E.,... Malfertheiner, P. (2017). Prevalence of Helicobacter pylori infection among blood donors in Saxony-Anhalt, Germany - A region at intermediate risk for gastric cancer. Zeitschrift für Gastroenterologie, 55(7), 653-656. https://doi.org/10.1055/s-0043-106311
MLA:
Franck, Caspar, et al. "Prevalence of Helicobacter pylori infection among blood donors in Saxony-Anhalt, Germany - A region at intermediate risk for gastric cancer." Zeitschrift für Gastroenterologie 55.7 (2017): 653-656.
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