Tiny Clusters for Big Impact in T Cell Activation
Le Saux G, Nowakowski P, Toledo E, Tzdaka S, Naaz S, Segal Y, Maman B, Pandit JJ, Iraqi M, Yassin AAK, Porgador A, Smith AS, Schvartzman M (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 25
Pages Range: 11878-11887
Journal Issue: 31
DOI: 10.1021/acs.nanolett.5c02361
Abstract
The regulation of T cell activation via engineered arrays holds significant biomedical potential. While average antibody density is known to influence T cell activation, antibody clustering has shown limited benefits. This study challenges this perspective through combined experimental and theoretical approaches. By employing nanolithographically patterned arrays, we show that full T cell activation is achievable with a small number of densely packed antibody clusters─even at average densities where homogeneous or sparsely clustered distributions are insufficient for full activation. These results align with the membrane-fluctuation model that considers cooperative binding and mechanical feedback. Our findings highlight the importance of the spatial organization of activating ligands and provide a framework for designing improved T cell activation platforms for immunotherapy.
Involved external institutions
Ben-Gurion University of the Negev (BGU) / אוניברסיטת בן-גוריון בנגב
Israel (IL)
Rudjer Boskovic Institute (RBI) / Institut Ruđer Bošković (IRB)
Croatia (HR)
Israel (IL)
Rudjer Boskovic Institute (RBI) / Institut Ruđer Bošković (IRB)
Croatia (HR)
How to cite
APA:
Le Saux, G., Nowakowski, P., Toledo, E., Tzdaka, S., Naaz, S., Segal, Y.,... Schvartzman, M. (2025). Tiny Clusters for Big Impact in T Cell Activation. Nano Letters, 25(31), 11878-11887. https://doi.org/10.1021/acs.nanolett.5c02361
MLA:
Le Saux, Guillaume, et al. "Tiny Clusters for Big Impact in T Cell Activation." Nano Letters 25.31 (2025): 11878-11887.
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