Case Report: Personalized peptide-based immunization in an advanced-stage prostate cancer patient with bone metastasis

Thoennissen NH, Martos-Contreras MC, Manoochehri M, Nogueira M, Bremm F, Dörrie J, Christoph J, Kunz M, Schönharting W (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Frontiers in Oncology Frontiers Media

Book Volume: 15

Article Number: 1596315

DOI: 10.3389/fonc.2025.1596315

Abstract

Neoantigens, which are recognized as non-self and trigger an immune response, are novel antigens generated by tumor cells. Here, we report a de novo metastatic hormone-sensitive prostate cancer (mHSPC) case, which benefited from our personalized peptide immunization named BioInformatic Tumor Address Peptides (BITAP) in a monotherapeutic setting. Our in-house bioinformatics pipeline involved identifying somatic variations, analyzing their expression, and computationally predicting novel epitopes from both metastatic and primary tumors, separately. As stand-alone therapy, the patient has been administered multiple injections of two peptide pools (BITAP-1 and BITAP-2). Several months following immunizations, a significant regression of both metastatic and primary tumor lesions was recorded along with low-level of prostate-specific antigen (PSA). Besides mild and short-lasting local and systemic reactions, no serious treatment-related adverse effects were reported by the patient. In conclusion, this case suggests that BITAP immunization is feasible and safe, and may present an immunotherapeutic approach inducing sustainable tumor regressions in mHSPC patients.

Authors with CRIS profile

Franziska Bremm Department of Dermatology Jan Dörrie Department of Dermatology

Involved external institutions

Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Universitätsklinikum Brandenburg an der Havel DE Germany (DE)

How to cite

APA:

Thoennissen, N.H., Martos-Contreras, M.C., Manoochehri, M., Nogueira, M., Bremm, F., Dörrie, J.,... Schönharting, W. (2025). Case Report: Personalized peptide-based immunization in an advanced-stage prostate cancer patient with bone metastasis. Frontiers in Oncology, 15. https://doi.org/10.3389/fonc.2025.1596315

MLA:

Thoennissen, Nils Heinrich, et al. "Case Report: Personalized peptide-based immunization in an advanced-stage prostate cancer patient with bone metastasis." Frontiers in Oncology 15 (2025).

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