Mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy (MOGHE): a report of the first case in Bulgaria.
Metodiev D, Minkin K, Dimova P, Blümcke I, Coras R, Ruseva M, Ganeva R, Parvanov D, Penkov M, Nachev S (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 63
Pages Range: 209-216
Journal Issue: 2
Abstract
Herein, we report the first case of mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) in Bulgaria. It is a newly recognised clinico-pathological entity with medically intractable focal epilepsy in paediatric patients. The patient of interest is a 9-year-old boy who has been suffering from refractory epilepsy since the age of three. Positron emission tomography revealed a consistent hypometabolism with maximum in the orbitofrontal and fronto-opercular cortex, as well as in the adjacent anterior insula and the anterior temporal regions. A left frontal corticotomy anterior from the precentral sulcus, left insulectomy and temporal disconnection were performed. Pathomorphological examination of the material from the resected brain tissues demonstrated oligodendroglial hyperplasia with blurring of grey-white-matter boundaries and presence of subcortical heterotopic neurones. Eighteen months post-surgically the patient is seizure-free and drug-free. The observed oligodendroglial hyperplasia with increased proliferative activity and heterotopic neurones in the white matter with blurring of grey-white-matter junctions are the histopathological hallmarks of MOGHE. More new cases are needed to establish further data about this distinct entity in frontal lobe epilepsy.
Authors with CRIS profile
Involved external institutions
Aleksandrovska University Hospital / университетска болница "Александровска"
Bulgaria (BG)
Nadezhda Hospital
Bulgaria (BG)
Bulgaria (BG)
Nadezhda Hospital
Bulgaria (BG)
How to cite
APA:
Metodiev, D., Minkin, K., Dimova, P., Blümcke, I., Coras, R., Ruseva, M.,... Nachev, S. (2025). Mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy (MOGHE): a report of the first case in Bulgaria. Folia Neuropathologica, 63(2), 209-216. https://doi.org/10.5114/fn.2024.138751
MLA:
Metodiev, Dimitar, et al. "Mild malformation of cortical development with oligodendroglial hyperplasia in frontal lobe epilepsy (MOGHE): a report of the first case in Bulgaria." Folia Neuropathologica 63.2 (2025): 209-216.
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