Long-lived cellular molecules in the brain

Hetzer MW, Toda T (2025)

Publication Type: Journal article, Review article

Publication year: 2025

Journal

Trends in Neurosciences Elsevier

DOI: 10.1016/j.tins.2025.07.004

Abstract

In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellular identity and plasticity to preserve brain function. Although extensive studies indicate the importance of recycling and regenerating cellular molecules to maintain cellular homeostasis, recent evidence has shown that some proteins and RNAs do not turn over for months and even years. We propose that these long-lived cellular molecules may be the basis for maintaining brain function in the long term, but also a potential convergent target of brain aging. We highlight key discoveries and challenges, and propose potential directions to unravel the mystery of brain cell longevity.

Authors with CRIS profile

Tomohisa Toda Professur für Neurale Epigenomik

Involved external institutions

Institute of Science and Technology Austria (IST Austria) AT Austria (AT)

How to cite

APA:

Hetzer, M.W., & Toda, T. (2025). Long-lived cellular molecules in the brain. Trends in Neurosciences. https://doi.org/10.1016/j.tins.2025.07.004

MLA:

Hetzer, Martin W., and Tomohisa Toda. "Long-lived cellular molecules in the brain." Trends in Neurosciences (2025).

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