Synergistic Physical and Chemical Cues Enhance Cellularization in Compartmentalized Microchannel Fibers Supplemented with Mesoporous Bioactive Glass Nanoparticles
Pedroza-González SC, Pérez González MP, Ochoa Tiscareño AF, Torres Acosta P, Vargas Mejía RE, Ulloa Castillo NA, Pérez Valverde MI, Sierra Valdez FJ, Boccaccini AR, Alvarez MM, Trujillo-De Santiago G (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Pages Range: 2765-2775
DOI: 10.1021/acsmaterialslett.5c00250
Abstract
The internal cellularization of thick tissue scaffolds remains a significant challenge in tissue engineering, often requiring costly and complex technologies. In this study, we developed a cost-effective, chaotic printing approach to fabricate compartmentalized hydrogel filaments that integrate physical and chemical cues. The physical cues, provided by hollow microchannels, enhance mass transport and nutrient exchange, while the chemical cues, delivered by mesoporous bioactive glass (BG) nanoparticles, facilitate sustained ion release, which can potentially support angiogenesis and cell migration. Characterization of the filaments demonstrated their structural integrity, controlled ion diffusion, and biocompatibility. In an ex ovo chick embryo model, the scaffolds supported cellularization and showed indications of promoting vascularization. This platform represents a promising step toward the development of functional scaffolds for applications in wound healing, in vitro models, and small tissue unit transplantation.
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Mexico (MX)How to cite
APA:
Pedroza-González, S.C., Pérez González, M.P., Ochoa Tiscareño, A.F., Torres Acosta, P., Vargas Mejía, R.E., Ulloa Castillo, N.A.,... Trujillo-De Santiago, G. (2025). Synergistic Physical and Chemical Cues Enhance Cellularization in Compartmentalized Microchannel Fibers Supplemented with Mesoporous Bioactive Glass Nanoparticles. ACS Materials Letters, 2765-2775. https://doi.org/10.1021/acsmaterialslett.5c00250
MLA:
Pedroza-González, Sara Cristina, et al. "Synergistic Physical and Chemical Cues Enhance Cellularization in Compartmentalized Microchannel Fibers Supplemented with Mesoporous Bioactive Glass Nanoparticles." ACS Materials Letters (2025): 2765-2775.
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