A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals

Jobin K, Seetharama D, Rüttger L, Fenton C, Kharybina E, Wirsching A, Huang A, Knöpper K, Kaisho T, Busch DH, Vaeth M, Saliba AE, Graw F, Pulfer A, González SF, Zehn D, Liang Y, Ugur M, Gasteiger G, Kastenmüller W (2025)


Publication Type: Journal article

Publication year: 2025

Journal

Book Volume: 388

Article Number: eadq1405

Journal Issue: 6743

DOI: 10.1126/science.adq1405

Abstract

T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their differentiation once they have disengaged from DCs and resumed their migration has been unclear. We identified a distinct priming phase that favors CD8 T cells expressing receptors with high affinity for antigen. CXCR3 expression by CD8 T cells was required for their hours-long reengagement with DCs in specific subfollicular niches in lymph nodes. CD4 T cells paused briefly at the sites of CD8 T cell and DC interactions and provided Interleukin-2 (IL-2) before moving to another DC. Our results highlight a previously unappreciated phase of cell-cell interactions during T cell priming and have direct implications for vaccinations and cellular immunotherapies.

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APA:

Jobin, K., Seetharama, D., Rüttger, L., Fenton, C., Kharybina, E., Wirsching, A.,... Kastenmüller, W. (2025). A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals. Science, 388(6743). https://doi.org/10.1126/science.adq1405

MLA:

Jobin, Katarzyna, et al. "A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals." Science 388.6743 (2025).

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