High-Resolution, Motion-Corrected, Volume-Fused OCT for Investigating Longitudinal Changes in Subretinal Drusenoid Deposits in Intermediate AMD

Won J, Yaghy A, Ploner S, Kaiser S, Girgis JM, Hwang Y, Jamil MU, Maier A, Waheed NK, Fujimoto JG (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Translational Vision Science & Technology Association for Research in Vision and Ophthalmology (ARVO)

Book Volume: 14

Article Number: 15

Journal Issue: 6

DOI: 10.1167/tvst.14.6.15

Abstract

Purpose: To demonstrate high-resolution, motion-corrected, volume-fused optical coherence tomography (OCT) for assessing longitudinal changes in macular dot form subretinal drusenoid deposits (SDDs). Methods: Six consecutive isotropic volume raster scans over 6 × 6 mm (500 × 500 A-scans) were acquired using a high-resolution (2.7 μm axial resolution) spectral domain OCT prototype instrument. OCT volumes were computationally motion-corrected and fused. The distribution and longitudinal changes in dot SDDs were evaluated using en face OCT in a 50-μm-thick slab, from 27 μm above Bruch’s membrane. Results: Computational motion correction and volume fusion methods improve visibility of small en face features and compensate for motion artifacts to facilitate longitudinal assessment. In total, 326 SDDs were identified in a representative series of four eyes from four patients with intermediate age-related macular degeneration (AMD) and assessed with a 3-to 12-month follow-up. Of the SDDs, 85.3% remained stable over the follow-up, while 9.8% regressed, 3.4% fused, and 1.5% new SDDs appeared. Conclusions: Computational motion correction and volume fusion combined with high-resolution OCT B-scans and en face slabs facilitate visualization and longitudinal tracking of focal pathologies, such as SDDs. Translational Relevance: The methods presented have the potential to improve OCT analysis of focal features, such as quantification of SDDs and other AMD biomarkers.

Authors with CRIS profile

Stefan Ploner Lehrstuhl für Informatik 5 (Mustererkennung)

Involved external institutions

Massachusetts Institute of Technology (MIT) US United States (USA) (US) New England Eye Center US United States (USA) (US)

How to cite

APA:

Won, J., Yaghy, A., Ploner, S., Kaiser, S., Girgis, J.M., Hwang, Y.,... Fujimoto, J.G. (2025). High-Resolution, Motion-Corrected, Volume-Fused OCT for Investigating Longitudinal Changes in Subretinal Drusenoid Deposits in Intermediate AMD. Translational Vision Science & Technology, 14(6). https://doi.org/10.1167/tvst.14.6.15

MLA:

Won, Jungeun, et al. "High-Resolution, Motion-Corrected, Volume-Fused OCT for Investigating Longitudinal Changes in Subretinal Drusenoid Deposits in Intermediate AMD." Translational Vision Science & Technology 14.6 (2025).

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