Renal Pathology Society/International Kidney and Monoclonal Gammopathy Research Group consensus on pathologic definitions and terminology of monoclonal gammopathy–associated kidney lesions

Nasr SH, Royal V, Best Rocha A, Büttner-Herold M, Roufosse C, Bridoux F, Ismail W, Bu L, Cornell LD, Dendooven A, Gupta RK, Hara S, Javaugue V, Kozakowski N, Kudose S, Méndez GP, Oliver K, Picken MM, Santoriello D, Sethi S, Shimizu A, Singh G, Stokes MB, Wang Sx, Leung N, Markowitz GS, D'Agati VD (2025)

Publication Type: Journal article

Publication year: 2025

Journal

DOI: 10.1016/j.kint.2025.04.007

Abstract

The spectrum of kidney lesions associated with monoclonal gammopathy has significantly expanded over the past 2 decades, with description of new entities and variants of old entities. Pathologic diagnosis is challenging because of lesional complexity, heterogeneity, and reliance on electron microscopy and ancillary techniques. A lack of precise pathologic definitions and uniform terminology has hampered diagnostic accuracy. To address these challenges, the Renal Pathology Society and International Kidney and Monoclonal Gammopathy Research Group jointly tasked a working group of nephropathologists and nephrologists to establish consensus-based terminology and definitions for monoclonal gammopathy–associated kidney lesions. Participants included experts in the field with international representation. This report presents their recommendations. For each lesion, prerequisite (mandatory) diagnostic criteria and supportive (nonmandatory) features are proposed. New terminology is provided for some lesions. Application of standardized terminology and definitions should help harmonize kidney biopsy diagnosis with precision therapy in the monoclonal gammopathy–associated kidney disorders.

Authors with CRIS profile

Involved external institutions

Mayo Clinic United States (USA) (US) Université de Montréal Canada (CA) Arkana Laboratories United States (USA) (US) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) Centre hospitalier universitaire de Poitiers (CHU de Poitiers) France (FR) Beni-Suef University / جامعة بني سويف Egypt (EG) University Hospital Ghent Belgium (BE) University of California Davis (UCDAVIS) United States (USA) (US) Kobe City Medical Center Japan (JP) Medizinische Universität Wien Austria (AT) Columbia University Irving Medical Center (CUIMC) United States (USA) (US) Princess Alexandra Hospital Australia (AU) Loyola University Medical Center United States (USA) (US) Nippon Medical School Japan (JP) All India Institute of Medical Sciences India (IN) Peking University First Hospital / 北大国际医院 China (CN)

How to cite

APA:

Nasr, S.H., Royal, V., Best Rocha, A., Büttner-Herold, M., Roufosse, C., Bridoux, F.,... D'Agati, V.D. (2025). Renal Pathology Society/International Kidney and Monoclonal Gammopathy Research Group consensus on pathologic definitions and terminology of monoclonal gammopathy–associated kidney lesions. Kidney International. https://doi.org/10.1016/j.kint.2025.04.007

MLA:

Nasr, Samih H., et al. "Renal Pathology Society/International Kidney and Monoclonal Gammopathy Research Group consensus on pathologic definitions and terminology of monoclonal gammopathy–associated kidney lesions." Kidney International (2025).

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