Introducing the Concept of Error Vectors to Improve Source Localization Results of Epileptic Discharges

Unnwongse K, Wolters CH, Wehner T, Krger LT, Rampp S, Wellmer J (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Journal of Clinical Neurophysiology Lippincott, Williams & Wilkins

Article Number: 10.1097/WNP.0000000000001170

DOI: 10.1097/WNP.0000000000001170

Abstract

Purpose:To improve EEG source localization results of interictal epileptic discharges (IED) by applying postprocessing step to electrical source imaging (ESI).Methods:Localization error of ESI was evaluated in comparison to known sources of stimulation potentials (ESP) by recording simultaneous stereo-EEG/scalp EEG. Error vectors were defined as the offset of the ESI-dipole of ESP to the stereo-EEG contacts used for stimulation. The inverted error vector was applied to the ESI-dipole of IED (IED-dipole).Results:Seven IED clusters were evaluated. Corrected IED-dipoles were located closer to IED-onset contacts on stereo-EEG than uncorrected IED-dipoles (median [IQR]: 7.8 [2.5] versus 18.7 [10.7] mm, P = 0.02). Anatomically, for high skull conductivities, all corrected IED-dipoles were located in cortical structures or adjacent to epileptogenic lesion, whereas uncorrected IED-dipoles were located in white matter or CSF (P = 0.02). Physiologically, cortical extent of IED generators estimated from corrected IED-dipoles was 16.5 cm2 (IQR = 10.4 cm2) and 7.4 cm2 (range 5.8-9.2 cm2) in the group of anterior temporal IED and prefrontal IED, respectively; the former was concordant with the extent estimated by subdural electrodes. In addition, the relationship of stereo-EEG IED amplitude (a) drop with increasing distance (d) from corrected IED-dipole could be modeled as a negative power equation a(d)∝1/db (R2 = 0.87, P < 0.01), with b ranging from 0.79 to 2.3, median: 1.57, consistent with a simulation model of the sensitivity of intracerebral electrode.Conclusions:Application of inverted error vector reduces localization error and shifts IED-dipole to an anatomically and physiologically plausible location.

Authors with CRIS profile

Stefan Rampp Department of Neurosurgery

Involved external institutions

Universitätsklinikum Knappschaftskrankenhaus Bochum DE Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster DE Germany (DE)

How to cite

APA:

Unnwongse, K., Wolters, C.H., Wehner, T., Krger, L.T., Rampp, S., & Wellmer, J. (2025). Introducing the Concept of Error Vectors to Improve Source Localization Results of Epileptic Discharges. Journal of Clinical Neurophysiology. https://doi.org/10.1097/WNP.0000000000001170

MLA:

Unnwongse, Kanjana, et al. "Introducing the Concept of Error Vectors to Improve Source Localization Results of Epileptic Discharges." Journal of Clinical Neurophysiology (2025).

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