Schaller S, Strnad V, Schweizer C, Lubgan D, Merten R, Fietkau R, Bert C, Karius A (2025)
Publication Type: Journal article
Publication year: 2025
Book Volume: 53
Article Number: 100968
DOI: 10.1016/j.ctro.2025.100968
Purpose: Model-based dose calculation algorithms (MBDCAs) are increasingly applied in brachytherapy, but their considerations in dose–response analyses is still lacking. This study aimed to assess correlations between both TG-43 and MBDCA dosimetry and reports on clinical outcomes for oral cavity brachytherapy. Methods: We considered 158 patients with oral cavity cancer treated in our institution between 2012 and 2021. Survival outcomes and toxicity (soft tissue necrosis, osteoradionecrosis, mucositis, xerostomia) were reported for a median follow-up of 80 months (2–152 months). All clinical, TG-43 based treatment plans were re-calculated using a MBDCA integrated into our planning system. Differences considering several target volume, tissue, and bone dose parameters were evaluated. Parameter correlations with clinical outcomes and thresholds associated with increased toxicity were investigated. Results: Cumulative local recurrence, soft-tissue necrosis, osteoradionecrosis, mucositis, and xerostomia rate were 21 %, 22 %, 28 % and 79 % considering all patients. Substantial differences between MBDCA and TG-43 were observed, especially regarding high-dose areas with changes up to 19 %. A number of dose-toxicity correlations were observed, as for osteoradionecrosis (1.6 % vs. 10.3 % for bone D
APA:
Schaller, S., Strnad, V., Schweizer, C., Lubgan, D., Merten, R., Fietkau, R.,... Karius, A. (2025). Comparison of dose calculation approaches and clinical dose–response in image-guided head&neck brachytherapy of the oral cavity. Clinical and Translational Radiation Oncology, 53. https://doi.org/10.1016/j.ctro.2025.100968
MLA:
Schaller, Sabrina, et al. "Comparison of dose calculation approaches and clinical dose–response in image-guided head&neck brachytherapy of the oral cavity." Clinical and Translational Radiation Oncology 53 (2025).
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