Modelling and Efficiency Enhancement of Tablet Coating in a Rotary Drum

Bück A, Singh AK, Palis S (2025)

Publication Type: Conference contribution

Publication year: 2025

Journal

Lecture Notes in Electrical Engineering Springer Verlag

Publisher: Springer Science and Business Media Deutschland GmbH

Book Volume: 1325 LNEE

Pages Range: 651-661

Conference Proceedings Title: Lecture Notes in Electrical Engineering

Event location: Porto, PRT PT

ISBN: 9783031817236

DOI: 10.1007/978-3-031-81724-3_58

Abstract

The paper focuses on optimizing coating efficiency in pharmaceutical tablet production. Coating tablets with active pharmaceutical ingredients (APIs) is crucial for controlling release rates. The process involves spraying a liquid onto a mixed tablet bed, where it forms a solid coating through evaporation. Homogeneity in coating thickness is vital for consistent API release. The study proposes a Monte-Carlo model for a rotary drum spray coater. Experimental validation shows good agreement between simulated and observed coating thickness distributions. Based on the proposed model different real-time optimization algorithms are explored to improve coating efficiency. Results highlight the importance of optimizing coating parameters for efficient and uniform tablet production, crucial for pharmaceutical quality control and cost-effectiveness.

Authors with CRIS profile

Andreas Bück Professur für Partikeltechnik Abhinandan Kumar Singh Professur für Partikeltechnik

Involved external institutions

Technische Universität Clausthal / Clausthal University of Technology DE Germany (DE)

How to cite

APA:

Bück, A., Singh, A.K., & Palis, S. (2025). Modelling and Efficiency Enhancement of Tablet Coating in a Rotary Drum. In Antonio Pedro Aguiar, Paula Rocha Malonek, Fernando A. C. C. Fontes, Roman Chertovskih, Vítor Hugo Pinto (Eds.), Lecture Notes in Electrical Engineering (pp. 651-661). Porto, PRT, PT: Springer Science and Business Media Deutschland GmbH.

MLA:

Bück, Andreas, Abhinandan Kumar Singh, and Stefan Palis. "Modelling and Efficiency Enhancement of Tablet Coating in a Rotary Drum." Proceedings of the 16th APCA International Conference on Automatic Control and Soft Computing, CONTROLO 2024, Porto, PRT Ed. Antonio Pedro Aguiar, Paula Rocha Malonek, Fernando A. C. C. Fontes, Roman Chertovskih, Vítor Hugo Pinto, Springer Science and Business Media Deutschland GmbH, 2025. 651-661.

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