Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment

Dib-Hajj SD, Binshtok AM, Cummins TR, Jarvis MF, Samad T, Zimmermann K (2009)

Publication Type: Journal article, Review article

Publication year: 2009

Journal

Brain Research Reviews Elsevier

Book Volume: 60

Pages Range: 65-83

Journal Issue: 1

DOI: 10.1016/j.brainresrev.2008.12.005

Abstract

Pain is a major unmet medical need which has been causally linked to changes in sodium channel expression, modulation, or mutations that alter channel gating properties or current density in nociceptor neurons. Voltage-gated sodium channels activate (open) then rapidly inactivate in response to a depolarization of the plasma membrane of excitable cells allowing the transient flow of sodium ions thus generating an inward current which underlies the generation and conduction of action potentials (AP) in these cells. Activation and inactivation, as well as other gating properties, of sodium channel isoforms have different kinetics and voltage-dependent properties, so that the ensemble of channels that are present determine the electrogenic properties of specific neurons. Biophysical and pharmacological studies have identified the peripheral-specific sodium channels Nav1.7, Nav1.8 and Nav1.9 as particularly important in the pathophysiology of different pain syndromes, and isoform-specific blockers of these channels or targeting their modulators hold the promise of a future effective therapy for treatment of pain. © 2008 Elsevier B.V. All rights reserved.

Involved external institutions

Yale School of Medicine US United States (USA) (US) Harvard University US United States (USA) (US) Indiana University – Purdue University Indianapolis US United States (USA) (US) Abbott US United States (USA) (US) Pfizer, Inc. US United States (USA) (US) Boston Children's Hospital US United States (USA) (US)

How to cite

APA:

Dib-Hajj, S.D., Binshtok, A.M., Cummins, T.R., Jarvis, M.F., Samad, T., & Zimmermann, K. (2009). Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment. Brain Research Reviews, 60(1), 65-83. https://doi.org/10.1016/j.brainresrev.2008.12.005

MLA:

Dib-Hajj, Sulayman D., et al. "Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment." Brain Research Reviews 60.1 (2009): 65-83.

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