The mechano-activated K± channels TRAAK and TREK-1 control both warm and cold perception
Noël J, Zimmermann K, Busserolles J, Deval E, Alloui A, Diochot S, Guy N, Borsotto M, Reeh P, Eschalier A, Lazdunski M (2009)
Publication Type: Journal article
Publication year: 2009
Journal
Book Volume: 28
Pages Range: 1308-1318
Journal Issue: 9
Abstract
The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat- and cold-sensitive excitatory transient receptor potential (TRP) channels. However, we show here that the mechano-gated and highly temperature-sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated. They are important for the definition of temperature thresholds and temperature ranges in which excitation of nociceptor takes place and for the intensity of excitation when it occurs. They are expressed with thermo-TRP channels in sensory neurons. TRAAK and TREK-1 channels control pain produced by mechanical stimulation and both heat and cold pain perception in mice. Expression of TRAAK alone or in association with TREK-1 controls heat responses of both capsaicin-sensitive and capsaicin-insensitive sensory neurons. Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol. © 2009 European Molecular Biology Organization | All Rights Reserved.
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APA:
Noël, J., Zimmermann, K., Busserolles, J., Deval, E., Alloui, A., Diochot, S.,... Lazdunski, M. (2009). The mechano-activated K± channels TRAAK and TREK-1 control both warm and cold perception. The EMBO Journal, 28(9), 1308-1318. https://doi.org/10.1038/emboj.2009.57
MLA:
Noël, Jacques, et al. "The mechano-activated K± channels TRAAK and TREK-1 control both warm and cold perception." The EMBO Journal 28.9 (2009): 1308-1318.
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