A Portable Chip-Based NMR Relaxometry System With Arbitrary Phase Control for Point-of-Care Blood Analysis.

Dreyer F, Yang Q, Alnajjar B, Kruger D, Blumich B, Anders J (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Ieee Transactions on Biomedical Circuits and Systems Institute of Electrical and Electronics Engineers (IEEE)

Book Volume: 17

Pages Range: 831-842

Journal Issue: 4

DOI: 10.1109/TBCAS.2023.3287281

Abstract

In this article, we present a portable NMR relaxometry system optimized for the point-of-care analysis of body liquids such as blood. The presented system is centered on an NMR-on-a-chip transceiver ASIC, a reference frequency generator with arbitrary phase control, and a custom-designed miniaturized NMR magnet with a field strength of 0.29 T and a total weight of 330 g. The NMR-ASIC co-integrates a low-IF receiver, a power amplifier, and a PLL-based frequency synthesizer on a total chip area of 1100 × 900 μm 2. The arbitrary reference frequency generator enables the use of conventional CPMG and inversion sequences, as well as modified water-suppression sequences. Moreover, it is used to implement an automatic frequency lock to correct temperature-induced magnetic field drifts. Proof-of-concept measurements on NMR phantoms and human blood samples show an excellent concentration sensitivity of v[Formula: see text] = 2.2 mM/[Formula: see text]. This very good performance renders the presented system an ideal candidate for the future NMR-based point-of-care detection of biomarkers such as the blood glucose concentration.

Involved external institutions

Universität Stuttgart DE Germany (DE) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE)

How to cite

APA:

Dreyer, F., Yang, Q., Alnajjar, B., Kruger, D., Blumich, B., & Anders, J. (2023). A Portable Chip-Based NMR Relaxometry System With Arbitrary Phase Control for Point-of-Care Blood Analysis. Ieee Transactions on Biomedical Circuits and Systems, 17(4), 831-842. https://doi.org/10.1109/TBCAS.2023.3287281

MLA:

Dreyer, Frederik, et al. "A Portable Chip-Based NMR Relaxometry System With Arbitrary Phase Control for Point-of-Care Blood Analysis." Ieee Transactions on Biomedical Circuits and Systems 17.4 (2023): 831-842.

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