Liver-intestine-cadherin is a sensitive marker of intestinal differentiation during barrett's carcinogenesis

Mokrowiecka A, Zonnur S, Veits L, Musial J, Kordek R, Lochowski M, Kozak J, Malecka-Panas E, Vieth M, Hartmann A (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Digestive Diseases and Sciences Springer Verlag (Germany)

Book Volume: 58

Pages Range: 699-705

Journal Issue: 3

DOI: 10.1007/s10620-012-2425-8

Abstract

Background: Histopathologic differentiation between the stages of Barrett's carcinogenesis is often challenging. Liver-intestine (LI)-cadherin, an intestine-specific marker, is involved in intestinal metaplasia development in gastric and colon cancers and could be of value in diagnosis and differentiation. Aims: To examine the expression of LI-cadherin in the sequence of Barrett's carcinogenesis and to evaluate its association with clinicopathological data. Methods: LI-cadherin expression was immunohistologically investigated, by use of anti-CDH17 antibody, in gastric mucosa (GM) biopsies taken from the cardia (n = 9), in Barrett's esophagus (BE) without intraepithelial neoplasia (without IEN) (n = 9) and BE with low-grade IEN (n = 11), and in esophageal adenocarcinoma (ADC) (n = 13). Results: The immunoreactivity score was highest in adenocarcinoma (mean IRS = 4.0), and dropped gradually from BE with IEN and BE without IEN (mean IRS = 2.0) to cardia mucosa (IRS = 0). Similarly, the intensity of staining and the percentage of positive cells increased during the sequential stages of BE carcinogenesis. Comparative analysis showed that LI-cadherin expression was significantly different between cardiac epithelium and ADC. Also, percentage of positive cells in GM was significantly different from that in BE with IEN. LI-cadherin IRS was lower for tumors with poor differentiation than for moderately differentiated tumors, but the difference was not statistically significant. Conclusions: LI-cadherin is a sensitive marker of intestinal metaplasia and can be helpful for early histologic diagnosis of Barrett's esophagus; it is, however, not significantly different between BE with and without IEN, and cannot be used to distinguish between these. © 2012 The Author(s).

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Medical University of Łódź / Uniwersytet Medyczny w Łodzi PL Poland (PL) Klinikum Bayreuth DE Germany (DE)

How to cite

APA:

Mokrowiecka, A., Zonnur, S., Veits, L., Musial, J., Kordek, R., Lochowski, M.,... Hartmann, A. (2013). Liver-intestine-cadherin is a sensitive marker of intestinal differentiation during barrett's carcinogenesis. Digestive Diseases and Sciences, 58(3), 699-705. https://doi.org/10.1007/s10620-012-2425-8

MLA:

Mokrowiecka, Anna, et al. "Liver-intestine-cadherin is a sensitive marker of intestinal differentiation during barrett's carcinogenesis." Digestive Diseases and Sciences 58.3 (2013): 699-705.

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