Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling
Feige MH, Vieth M, Sokolova O, Täger C, Naumann M (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 1865
Pages Range: 545-550
Journal Issue: 4
DOI: 10.1016/j.bbamcr.2018.01.006
Abstract
The pathogen Helicobacter pylori, which infects half of the world's population, is a major risk factor for the development of gastric diseases including chronic gastritis and gastric cancer. Among H. pylori's virulence factors is the cytotoxin-associated gene pathogenicity island (cagPAI), which encodes for a type IV secretion system (T4SS). The T4SS induces fast canonical nuclear factor-kappa B (NF-κB) signaling, a major factor increasing inflammation, supressing apoptotic cell death and thereby promoting the development of neoplasia. However, H. pylori's capability to mediate fast non-canonical NF-κB signaling is unresolved, despite a contribution of non-canonical NF-κB signaling to gastric cancer has been suggested. We analyzed signaling elements within non-canonical NF-κB in response to H. pylori in epithelial cell lines by immunoprecipitation, immunoblot, electrophoretic mobility shift assay and RNA interference knockdown. In addition, tissue samples of H. pylori-infected patients were investigated by immunohistochemistry. Here, we provide evidence for a T4SS-dependent direct activation of non-canonical NF-κB signaling. We identified the lymphotoxin beta receptor (LTβR) to elicit the fast release of NF-κB inducing kinase (NIK) from the receptor complex leading to non-canonical NF-κB signaling. Further, NIK expression was increased in human biopsies of H. pylori-associated gastritis. Thus, NIK could represent a novel target to reduce Helicobacter pylori-induced gastric inflammation and pathology.
Involved external institutions
Germany (DE)How to cite
APA:
Feige, M.H., Vieth, M., Sokolova, O., Täger, C., & Naumann, M. (2018). Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling. Biochimica Et Biophysica Acta-Molecular Cell Research, 1865(4), 545-550. https://doi.org/10.1016/j.bbamcr.2018.01.006
MLA:
Feige, Michael Hartmut, et al. "Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling." Biochimica Et Biophysica Acta-Molecular Cell Research 1865.4 (2018): 545-550.
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