Ultrasound Super-Resolution Imaging of Neonatal Cerebral Vascular Reorganization

Schwarz S, Denis L, Nedoschill E, Bühler A, Danko V, Hilger A, Brevis Nuñez F, Dürr NR, Schlunz-Hendann M, Brassel F, Felderhoff-Müser U, Reutter HM, Wölfle J, Jüngert JM, Dohna-Schwake C, Bruns N, Regensburger A, Couture O, Mandelbaum H, Knieling F (2025)

Publication Language: English

Publication Type: Journal article

Publication year: 2025

Journal

Advanced Science Wiley Open Access

Book Volume: 12

Article Number: 2415235

Journal Issue: 12

DOI: 10.1002/advs.202415235

Abstract

During the first days of neonatal growth, the central nervous system (CNS) develops self-regulatory mechanisms to ensure constant cerebral perfusion. However, this vascular neogenesis takes place at a microscopic scale that cannot be observed with current clinical imaging techniques. Ultrasound localization microscopy (ULM) allows us to observe micro-vessels of the order of a few microns at depths of several centimeters. This can be done using conventional clinical ultrasound scanners and contrast sequences (CEUS). In this study, ULM is used to observe the human microvasculature in neonatal patients undergoing treatment for life-threatening malformations forming direct connections between the cerebral arterial and venous systems. It is observed that neuroendovascular treatment of neonatal arteriovenous malformations causes remodeling and reorganization of the cerebral vasculature by also activating corticomedullary vascular connections. ULM enables us to follow microvascular changes in human neonates with high spatio-temporal resolution. ULM may provide a novel clinical translatable tool, particularly including cerebral imaging in very young patients.

Authors with CRIS profile

Alina Hilger Department of Paediatrics and Adolescent Medicine Heiko Martin Reutter Professur für Neonatologie Joachim Wölfle Lehrstuhl für Kinder- und Jugendmedizin Jörg Jüngert Department of Paediatrics and Adolescent Medicine Adrian Regensburger Department of Paediatrics and Adolescent Medicine Henriette Mandelbaum Department of Paediatrics and Adolescent Medicine Ferdinand Knieling Department of Paediatrics and Adolescent Medicine

Involved external institutions

Sana Kliniken AG DE Germany (DE) Biomedical Imaging Lab / Laboratoire d’Imagerie Biomédicale (LIB) FR France (FR) Universitätsklinikum Essen DE Germany (DE)

How to cite

APA:

Schwarz, S., Denis, L., Nedoschill, E., Bühler, A., Danko, V., Hilger, A.,... Knieling, F. (2025). Ultrasound Super-Resolution Imaging of Neonatal Cerebral Vascular Reorganization. Advanced Science, 12(12). https://doi.org/10.1002/advs.202415235

MLA:

Schwarz, Simone, et al. "Ultrasound Super-Resolution Imaging of Neonatal Cerebral Vascular Reorganization." Advanced Science 12.12 (2025).

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