Prognostic Significance of the Detection of Human Papilloma Virus L1 Protein in Smears of Cervical Intraepithelial Neoplasia Grade 3 in Pregnant Women

Stübs F, Dietl A, Schulmeyer C, Behrens A, Seibold A, Brückner L, Schleicher O, Adler W, Geppert CI, Hartmann A, Hartman A, Knöll A, Beckmann M, Gaß P, Hilfrich R, Mehlhorn G (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Anticancer Research International Institute of Anticancer Research (IIAR)

Book Volume: 45

Pages Range: 677-683

Journal Issue: 2

DOI: 10.21873/anticanres.17455

Abstract

Background/Aim: Cervical intraepithelial neoplasia (CIN) III/high-grade squamous lesions (HSIL) remains a significant challenge during pregnancy. Current data on the course of disease are contradictory, with cases of progression to cervical cancer (CC) during pregnancy being observed. Evidence suggests that the expression of L1 capsid protein is associated with a favorable prognosis in non-pregnant women.

Authors with CRIS profile

Frederik Stübs Department of Obstetrics and Gynaecology Anna Dietl Department of Obstetrics and Gynaecology Carla Schulmeyer Department of Obstetrics and Gynaecology Annika Behrens Department of Obstetrics and Gynaecology Anja Seibold Department of Obstetrics and Gynaecology Lena Brückner Department of Obstetrics and Gynaecology Oliver Schleicher Department of Obstetrics and Gynaecology Werner Adler Lehrstuhl für Biometrie und Epidemiologie (IMBE) Carol-Immanuel Geppert Institute of Pathology Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Antje Knöll Institute of Clinical and Molecular Virology Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Paul Gaß Department of Obstetrics and Gynaecology

Involved external institutions

Cytoimmun Diagnostics GmbH DE Germany (DE) Deutsche Krebsgesellschaft (DKG) DE Germany (DE)

How to cite

APA:

Stübs, F., Dietl, A., Schulmeyer, C., Behrens, A., Seibold, A., Brückner, L.,... Mehlhorn, G. (2025). Prognostic Significance of the Detection of Human Papilloma Virus L1 Protein in Smears of Cervical Intraepithelial Neoplasia Grade 3 in Pregnant Women. Anticancer Research, 45(2), 677-683. https://doi.org/10.21873/anticanres.17455

MLA:

Stübs, Frederik, et al. "Prognostic Significance of the Detection of Human Papilloma Virus L1 Protein in Smears of Cervical Intraepithelial Neoplasia Grade 3 in Pregnant Women." Anticancer Research 45.2 (2025): 677-683.

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