The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing

Amunts K, Axer M, Banerjee S, Bitsch L, Bjaalie JG, Brauner P, Brovelli A, Calarco N, Carrere M, Caspers S, Charvet CJ, Cichon S, Cools R, Costantini I, D’Angelo EU, De Bonis G, Deco G, DeFelipe J, Destexhe A, Dickscheid T, Diesmann M, Düzel E, Eickhoff SB, Einevoll G, Eke D, Engel AK, Evans AC, Evers K, Fedorchenko N, Forkel SJ, Fousek J, Friederici AD, Friston KJ, Furber S, Geris L, Goebel R, Güntürkün O, Hamid AIA, Herold C, Hilgetag CC, Hoelter SM, Ioannidis Y, Jirsa V, Kashyap S, Kasper BS, de Kerchove d’Exaerde A, Kooijmans R, Koren I, Hellgren Kotaleski J, Kiar G, Klijn W, Klüver L, Knoll AC, Krsnik Z, Kämpfer J, Larkum ME, Linne ML, Lippert T, Abdullah JM, Di Maio P, Magielse N, Maquet P, Allegra Mascaro AL, Marinazzo D, Mejias J, Meyer-Lindenberg A, Migliore M, Michael J, Morel Y, Morin FO, Muckli L, Nagels G, Oden L, Palomero-Gallagher N, Panagiotaropoulos F, Stanislao Paolucci P, Pennartz C, Peeters LM, Petkoski S, Petkov N, Petro LS, Petrovici MA, Pezzulo G, Roelfsema P, Ris L, Ritter P, Rockland K, Rotter S, Rowald A, Ruland S, Ryvlin P, Salles A, Sanchez-Vives MV, Schemmel J, Senn W, de Sousa AA, Ströckens F, Thirion B, Uludağ K, Vanni S, van Albada SJ, Vanduffel W, Vezoli J, Vincenz-Donnelly L, Walter F, Zaborszky L (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 2

Pages Range: 1-35

DOI: 10.1162/imag_a_00137

Abstract

In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modelling at multiple scales—from molecules to the whole brain. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain combines high-quality research, data integration across multiple scales, a new culture of multidisciplinary large-scale collaboration, and translation into applications. As pioneered in Europe’s Human Brain Project (HBP), a systematic approach will be essential for meeting the coming decade’s pressing medical and technological challenges. The aims of this paper are to: develop a concept for the coming decade of digital brain research, discuss this new concept with the research community at large, identify points of convergence, and derive therefrom scientific common goals; provide a scientific framework for the current and future development of EBRAINS, a research infrastructure resulting from the HBP’s work; inform and engage stakeholders, funding organisations and research institutions regarding future digital brain research; identify and address the transformational potential of comprehensive brain models for artificial intelligence, including machine learning and deep learning; outline a collaborative approach that integrates reflection, dialogues, and societal engagement on ethical and societal opportunities and challenges as part of future neuroscience research.

Authors with CRIS profile

Involved external institutions

Forschungszentrum Jülich / Research Centre Jülich (FZJ) Germany (DE) CNRS / Center of Oceanology of Marseille (COM) La-Seyne-Sur-Mer France (FR) Universidad Politécnica de Madrid (UPM) Spain (ES) Auburn University United States (USA) (US) Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Germany (DE) The Danish Board of Technology Foundation Denmark (DK) University of Oslo Norway (NO) Université Paris-Saclay France (FR) Max-Planck-Institut für Kognitions- und Neurowissenschaften / Max Planck Institute for Human Cognitive and Brain Sciences Germany (DE) Uppsala University Sweden (SE) Universitätsspital Basel Switzerland (CH) Heinrich-Heine-Universität Düsseldorf Germany (DE) Radboud University Nijmegen Netherlands (NL) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) Montreal Neurological Institute and Hospital (MNI, The Neuro) Canada (CA) Bergische Universität Wuppertal Germany (DE) Università degli Studi di Firenze / University of Florence Italy (IT) University College London (UCL) United Kingdom (GB) Universitat Pompeu Fabra (UPF) Spain (ES) University of Toronto Canada (CA) Aix-Marseille University / Aix-Marseille Université France (FR) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Germany (DE) Maastricht University Netherlands (NL) Boston University United States (USA) (US) Harokopio University / Χαροκόπειο Πανεπιστήμιο Greece (GR) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) National Institute for Nuclear Physics / Istituto Nazionale di Fisica Nucleare (INFN) Italy (IT) University of Science Malaysia (USM) / Universiti Sains Malaysia Malaysia (MY) Université libre de Bruxelles (ULB) / Free University of Brussels Belgium (BE) University of Zagreb / Sveučilište u Zagrebu Croatia (HR) Child Mind Institute United States (USA) (US) Peter Grünberg Institut (PGI, Forschungszentrum Jülich) Germany (DE) Humboldt-Universität zu Berlin Germany (DE) Jülich Aachen Research Alliance (JARA) Germany (DE) Royal Institute of Technology / Kungliga Tekniska Högskolan (KTH) Sweden (SE) University of Tampere (UTA) / Tampereen yliopisto (Tay) Finland (FI) University of Liège (ULg) / Université de Liège Belgium (BE) Ronin Institute United States (USA) (US) Medizinische Fakultät Mannheim der Universität Heidelberg Germany (DE) University of Amsterdam Netherlands (NL) Universiteit Gent (UGent) / Ghent University Belgium (BE) Consiglio Nazionale delle Ricerche (CNR) / National Research Council of Italy Italy (IT) Technische Universität München (TUM) Germany (DE) University Health Network (UHN) Canada (CA) University of Glasgow United Kingdom (GB) Université Paris-Sud France (FR) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) FernUniversität in Hagen Germany (DE) Vrije Universiteit Brussel (VUB) Belgium (BE) Sorbonne Université France (FR) University of Mons / Université de Mons Belgium (BE) University of Groningen / Rijksuniversiteit Groningen Netherlands (NL) Hasselt University / Universiteit Hasselt Belgium (BE) Université de Lausanne (UNIL) Switzerland (CH) Norwegian University of Life Sciences (NMBU) Norway (NO) Albert-Ludwigs-Universität Freiburg Germany (DE) University of Manchester United Kingdom (GB) Charité - Universitätsmedizin Berlin Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) De Montfort University United Kingdom (GB) Università degli Studi di Pavia Italy (IT) Inria Saclay - Île-de-France Research Centre France (FR) Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Roma I Italy (IT) Université Claude Bernard Lyon 1 (UCB) France (FR) University of Bath United Kingdom (GB) Helsingin yliopisto / University of Helsinki Finland (FI) Rutgers, The State University of New Jersey United States (USA) (US) Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Spain (ES) Universität Bern Switzerland (CH) Universität zu Köln Germany (DE)

How to cite

APA:

Amunts, K., Axer, M., Banerjee, S., Bitsch, L., Bjaalie, J.G., Brauner, P.,... Zaborszky, L. (2024). The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing. Imaging Neuroscience, 2, 1-35. https://doi.org/10.1162/imag_a_00137

MLA:

Amunts, Katrin, et al. "The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing." Imaging Neuroscience 2 (2024): 1-35.

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