The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing

Amunts K, Axer M, Banerjee S, Bitsch L, Bjaalie JG, Brauner P, Brovelli A, Calarco N, Carrere M, Caspers S, Charvet CJ, Cichon S, Cools R, Costantini I, D’Angelo EU, De Bonis G, Deco G, DeFelipe J, Destexhe A, Dickscheid T, Diesmann M, Düzel E, Eickhoff SB, Einevoll G, Eke D, Engel AK, Evans AC, Evers K, Fedorchenko N, Forkel SJ, Fousek J, Friederici AD, Friston KJ, Furber S, Geris L, Goebel R, Güntürkün O, Hamid AIA, Herold C, Hilgetag CC, Hoelter SM, Ioannidis Y, Jirsa V, Kashyap S, Kasper BS, de Kerchove d’Exaerde A, Kooijmans R, Koren I, Hellgren Kotaleski J, Kiar G, Klijn W, Klüver L, Knoll AC, Krsnik Z, Kämpfer J, Larkum ME, Linne ML, Lippert T, Abdullah JM, Di Maio P, Magielse N, Maquet P, Allegra Mascaro AL, Marinazzo D, Mejias J, Meyer-Lindenberg A, Migliore M, Michael J, Morel Y, Morin FO, Muckli L, Nagels G, Oden L, Palomero-Gallagher N, Panagiotaropoulos F, Stanislao Paolucci P, Pennartz C, Peeters LM, Petkoski S, Petkov N, Petro LS, Petrovici MA, Pezzulo G, Roelfsema P, Ris L, Ritter P, Rockland K, Rotter S, Rowald A, Ruland S, Ryvlin P, Salles A, Sanchez-Vives MV, Schemmel J, Senn W, de Sousa AA, Ströckens F, Thirion B, Uludağ K, Vanni S, van Albada SJ, Vanduffel W, Vezoli J, Vincenz-Donnelly L, Walter F, Zaborszky L (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 2

Pages Range: 1-35

DOI: 10.1162/imag_a_00137

Abstract

In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modelling at multiple scales—from molecules to the whole brain. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain combines high-quality research, data integration across multiple scales, a new culture of multidisciplinary large-scale collaboration, and translation into applications. As pioneered in Europe’s Human Brain Project (HBP), a systematic approach will be essential for meeting the coming decade’s pressing medical and technological challenges. The aims of this paper are to: develop a concept for the coming decade of digital brain research, discuss this new concept with the research community at large, identify points of convergence, and derive therefrom scientific common goals; provide a scientific framework for the current and future development of EBRAINS, a research infrastructure resulting from the HBP’s work; inform and engage stakeholders, funding organisations and research institutions regarding future digital brain research; identify and address the transformational potential of comprehensive brain models for artificial intelligence, including machine learning and deep learning; outline a collaborative approach that integrates reflection, dialogues, and societal engagement on ethical and societal opportunities and challenges as part of future neuroscience research.

Authors with CRIS profile

Involved external institutions

Université Paris-Saclay France (FR) Forschungszentrum Jülich / Research Centre Jülich (FZJ) Germany (DE) University of Oslo Norway (NO) The Danish Board of Technology Foundation Denmark (DK) University of Toronto Canada (CA) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Germany (DE) CNRS / Center of Oceanology of Marseille (COM) La-Seyne-Sur-Mer France (FR) Bergische Universität Wuppertal Germany (DE) Auburn University United States (USA) (US) Universitätsspital Basel Switzerland (CH) Radboud University Nijmegen Netherlands (NL) Università degli Studi di Firenze / University of Florence Italy (IT) Università degli Studi di Pavia Italy (IT) National Institute for Nuclear Physics / Istituto Nazionale di Fisica Nucleare (INFN) Italy (IT) Heinrich-Heine-Universität Düsseldorf Germany (DE) Universidad Politécnica de Madrid (UPM) Spain (ES) Universitat Pompeu Fabra (UPF) Spain (ES) Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Germany (DE) University Health Network (UHN) Canada (CA) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Norwegian University of Life Sciences (NMBU) Norway (NO) Boston University United States (USA) (US) University of Science Malaysia (USM) / Universiti Sains Malaysia Malaysia (MY) Harokopio University / Χαροκόπειο Πανεπιστήμιο Greece (GR) University of Manchester United Kingdom (GB) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) Aix-Marseille University / Aix-Marseille Université France (FR) Université libre de Bruxelles (ULB) / Free University of Brussels Belgium (BE) Max-Planck-Institut für Kognitions- und Neurowissenschaften / Max Planck Institute for Human Cognitive and Brain Sciences Germany (DE) University College London (UCL) United Kingdom (GB) De Montfort University United Kingdom (GB) Maastricht University Netherlands (NL) Montreal Neurological Institute and Hospital (MNI, The Neuro) Canada (CA) Uppsala University Sweden (SE) University of Zagreb / Sveučilište u Zagrebu Croatia (HR) Technische Universität München (TUM) Germany (DE) Humboldt-Universität zu Berlin Germany (DE) Jülich Aachen Research Alliance (JARA) Germany (DE) Royal Institute of Technology / Kungliga Tekniska Högskolan (KTH) Sweden (SE) University of Tampere (UTA) / Tampereen yliopisto (Tay) Finland (FI) Child Mind Institute United States (USA) (US) Peter Grünberg Institut (PGI, Forschungszentrum Jülich) Germany (DE) University of Liège (ULg) / Université de Liège Belgium (BE) Ronin Institute United States (USA) (US) Consiglio Nazionale delle Ricerche (CNR) / National Research Council of Italy Italy (IT) Medizinische Fakultät Mannheim der Universität Heidelberg Germany (DE) University of Amsterdam Netherlands (NL) University of Glasgow United Kingdom (GB) Universiteit Gent (UGent) / Ghent University Belgium (BE) Université Paris-Sud France (FR) FernUniversität in Hagen Germany (DE) Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Roma I Italy (IT) Universität Bern Switzerland (CH) Sorbonne Université France (FR) University of Mons / Université de Mons Belgium (BE) University of Groningen / Rijksuniversiteit Groningen Netherlands (NL) Hasselt University / Universiteit Hasselt Belgium (BE) Charité - Universitätsmedizin Berlin Germany (DE) Albert-Ludwigs-Universität Freiburg Germany (DE) Université de Lausanne (UNIL) Switzerland (CH) Vrije Universiteit Brussel (VUB) Belgium (BE) Universität zu Köln Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Inria Saclay - Île-de-France Research Centre France (FR) Université Claude Bernard Lyon 1 (UCB) France (FR) University of Bath United Kingdom (GB) Helsingin yliopisto / University of Helsinki Finland (FI) Rutgers, The State University of New Jersey United States (USA) (US) Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Spain (ES)

How to cite

APA:

Amunts, K., Axer, M., Banerjee, S., Bitsch, L., Bjaalie, J.G., Brauner, P.,... Zaborszky, L. (2024). The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing. Imaging Neuroscience, 2, 1-35. https://doi.org/10.1162/imag_a_00137

MLA:

Amunts, Katrin, et al. "The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing." Imaging Neuroscience 2 (2024): 1-35.

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