Schmidkonz C, Kuwert T, Götz TI, Ramming A, Atzinger A (2024)
Publication Type: Journal article, Review article
Publication year: 2024
DOI: 10.1007/s00256-024-04834-w
Imaging molecular processes associated with inflammatory disease has been revolutionized by hybrid imaging using positron emission tomography/computed tomography (PET/CT). PET/CT visualizes metabolic activity as well as protein expression and provides a comprehensive whole-body evaluation. It has the potential to reveal inflammation prior to detection of structural changes in inflammatory joint diseases. FAP is a type II transmembrane glycoprotein overexpressed not only in the stroma of tumors but also in the fibrotic processes of certain immune-mediated disorders. The recent introduction of fibroblast activation protein inhibitors (FAPI) labeled by positron emitters and thus suitable for PET/CT allows to investigate FAP expression in vivo. This review will focus on the use of FAPI-PET/CT for the diagnosis and evaluation of treatment response in inflammatory joint diseases.
APA:
Schmidkonz, C., Kuwert, T., Götz, T.I., Ramming, A., & Atzinger, A. (2024). Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT. Skeletal Radiology. https://doi.org/10.1007/s00256-024-04834-w
MLA:
Schmidkonz, Christian, et al. "Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT." Skeletal Radiology (2024).
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