Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT
Schmidkonz C, Kuwert T, Götz TI, Ramming A, Atzinger A (2024)
Publication Type: Journal article, Review article
Publication year: 2024
Journal
DOI: 10.1007/s00256-024-04834-w
Abstract
Imaging molecular processes associated with inflammatory disease has been revolutionized by hybrid imaging using positron emission tomography/computed tomography (PET/CT). PET/CT visualizes metabolic activity as well as protein expression and provides a comprehensive whole-body evaluation. It has the potential to reveal inflammation prior to detection of structural changes in inflammatory joint diseases. FAP is a type II transmembrane glycoprotein overexpressed not only in the stroma of tumors but also in the fibrotic processes of certain immune-mediated disorders. The recent introduction of fibroblast activation protein inhibitors (FAPI) labeled by positron emitters and thus suitable for PET/CT allows to investigate FAP expression in vivo. This review will focus on the use of FAPI-PET/CT for the diagnosis and evaluation of treatment response in inflammatory joint diseases.
Authors with CRIS profile
Christian Schmidkonz
Medizinische Fakultät
Torsten Kuwert
Lehrstuhl für Klinische Nuklearmedizin
Andreas Ramming
Medizinische Fakultät
Armin Atzinger
Department of Nuclear Medicine
Involved external institutions
Germany (DE)How to cite
APA:
Schmidkonz, C., Kuwert, T., Götz, T.I., Ramming, A., & Atzinger, A. (2024). Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT. Skeletal Radiology. https://doi.org/10.1007/s00256-024-04834-w
MLA:
Schmidkonz, Christian, et al. "Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT." Skeletal Radiology (2024).
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