The effect of carbamazepine, a strong CYP3A inducer, on the pharmacokinetics of zongertinib in healthy male volunteers

Tian X, Esmaeili H, Minich D, Seitz F, Roessner PM, Wind S, Grempler R, Gan G, Chan TS, Mahmoudi M, Sadrolhefazi B, Müller F (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Pharmacotherapy Wiley-Blackwell

DOI: 10.1002/phar.4641

Abstract

Introduction: Zongertinib (BI 1810631) is a potent, selective, and epidermal growth factor receptor (EGFR) wild-type sparing human epidermal growth factor receptor 2 (HER2) inhibitor. Based on in vitro data, the oxidative hepatic metabolism of zongertinib is principally driven by cytochrome P450 (CYP) 3A4/5. Therefore, zongertinib may be affected by strong CYP3A inducers, like carbamazepine. Objective: This study aimed to investigate the effect of multiple oral doses of carbamazepine on the pharmacokinetics of a single oral dose of zongertinib in healthy male subjects. Methods: This open-label, two-period, fixed-sequence clinical drug–drug interaction study examined the pharmacokinetics of a single 60-mg oral dose of zongertinib in the absence or presence of multiple oral doses of carbamazepine. The extent of drug–drug interaction was estimated using the adjusted geometric mean ratios (and 90% confidence intervals [CIs]) for the test treatment (zongertinib in the presence of carbamazepine) versus the reference treatment (zongertinib alone) for areas under the plasma concentration–time curve from time 0 to infinity and to the last quantifiable time point (AUC0–∞, AUC0–tz) and maximum measured plasma concentration (Cmax). Results: Sixteen subjects (all Caucasian males) received zongertinib alone in Study Period 1, and 15 of them received both zongertinib and carbamazepine in Study Period 2. Upon co-administration with carbamazepine in Study Period 2, AUC0–∞ and AUC0–tz of zongertinib were both reduced to 36.5% (90% CI: 32.0%–41.6% for AUC0–∞ and 31.9%–41.7% for AUC0–tz). The Cmax of zongertinib was reduced to 56.4% (90% CI: 45.1%–70.6%). Conclusion: Zongertinib exposure was reduced by 63.5% when coadministered with the strong CYP3A inducer, carbamazepine.

Involved external institutions

Boehringer Ingelheim Pharma GmbH & Co. KG DE Germany (DE) LMU Klinikum DE Germany (DE) CRS Clinical Research Services Mannheim GmbH DE Germany (DE)

How to cite

APA:

Tian, X., Esmaeili, H., Minich, D., Seitz, F., Roessner, P.M., Wind, S.,... Müller, F. (2024). The effect of carbamazepine, a strong CYP3A inducer, on the pharmacokinetics of zongertinib in healthy male volunteers. Pharmacotherapy. https://doi.org/10.1002/phar.4641

MLA:

Tian, Xiaofan, et al. "The effect of carbamazepine, a strong CYP3A inducer, on the pharmacokinetics of zongertinib in healthy male volunteers." Pharmacotherapy (2024).

BibTeX: Download