The role of LIN28B in tumor progression and metastasis in solid tumor entities.
Gewalt T, Noh KW, Meder L (2023)
Publication Type: Journal article, Review article
Publication year: 2023
Journal
Book Volume: 31
Pages Range: 101-115
Journal Issue: 2
Abstract
LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic properties. In this review, we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.
Involved external institutions
Germany (DE)How to cite
APA:
Gewalt, T., Noh, K.W., & Meder, L. (2023). The role of LIN28B in tumor progression and metastasis in solid tumor entities. Oncology Research, 31(2), 101-115. https://doi.org/10.32604/or.2023.028105
MLA:
Gewalt, Tabea, Ka Won Noh, and Lydia Meder. "The role of LIN28B in tumor progression and metastasis in solid tumor entities." Oncology Research 31.2 (2023): 101-115.
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