Karbiener M, Kindle G, Meyts I, Seppänen MR, Candotti F, Kamieniak M, Ilk R, Kreil TR, Seidel MG, Abd Elaziz D, Abdelkader Sohilla LM, Abitbol A, Hassan A, Abrahim L, Abuzakouk M, Achir MN, Afonso V, Agyeman P, Ahlmann M, Aiuti A, Akl A, Aksu G, Albers K, Albert M, Alecsandru MD, Aleinikova O, Aleshkevich S, Allende L, Alligon M, Allwood Z, Alsina MdLL, Ambrosch‐barsoumian D, Ameshofer L, Amour K, Anadol E, Ananthachagaran A, Andriamanga C, Andris J, Andritschke K, Angelini F, Ankermann T, Apel K, Arami S, Ardeniz Ö, Arkwright P, Arnold K, Ascherl R, Assam N, Assia-Batzir N, Atschekzei F, Aumann S, Aumann V, Aurivillius M, Ausserer B, Avcin T, Aydemir S, Aygören-Pürsün E, Ayvaz DC, de Azevedo Amaral CB, Azzari C, Babacar L, Bach P, Bachmann S, Bader P, Bakhtiar S, Bancé R, Bangs C, Baratault MS, Barfusz K, Baris S, Barlan IB, Bartsch M, Baumann H, Baumann U, Baumeister V, Baxendale H, Bazen S, Beaurain B, Beauté J, Beck N, Becker B, Becker C, Behrends U, Beider R, Beier R, Belke L, Bellert S, Belohradsky BH, Ben Slama L, Ben-Bouzid A, Berdous-Samed T, Bergils J, Berglöf A, Bergman P, Bernatoniene J, Bernatowska E, Bernat-Sitarz K, Bernbeck B, Bethune C, Beuckmann K, Bhole M, Biegner AK, Bielack S, Bienemann K, Bigl A, Bigorgne A, Bijl M, Binder N, Bitzenhofer‐grüber M, Blanchard RG, Blank D, Blattmann C, Blau J, Blaziene A, Blazina S, Blume R, Boardman B, Bode S, Boelens JJ, Boesecke C, Bogaert D, Bogner J, Bohynikova N, Booth C, Bordon V, Borkhardt A, Borte M, Borte S, Bossaller L, Bossard M, Botros J, Boucherit S, Boutros J, Boyarchuk O, Boyman O, Boztug K, Braschler T, Bravo S, Bredius R, Bright P, Brodszki N, Brodt G, Brolund A, Brosselin P, Brummel B, Brunner J, Bruns R, Brun-Schmid S, Buchta C, Buck D, Bücker A, Buckland M, Bührlen M, Burdach S, Burns S, Burton J, Caminal L, Cancrini C, Canessa C, Cant AJ, Cantoni N, Capilna B, Caracseghi F, Caragol I, Carbone J, Carrabba M, Chamberlain L, Chantrain C, Chapel H, Chassot J, Chee R, Chinello M, Chopra C, Chovancova Z, Christmann M, Chrzanowska K, Ciznar P, Claes K, Classen CF, Classen M, Cochino AV, Corbacioglu S, Cordeiro AI, Cordier WD, Core C, Costes L, Coulter T, Courteille V, Cristina M, Cucuruz M, Dabrowska LN, Dähling M, Daly ML, Daniel CS, Danieli M, Danieli MG, Darroch J, Davies G, de Baets F, De Boeck C, De Gracia J, De Gracia RJ, de Nadai N, de Schutter I, De Vergnes N, de Vries E, Debert T, Debré M, Defila C, Deimel J, Delaplace D, Dellepiane RM, Dellert N, Delliera L, Delor A, Demel U, Dempster J, Den Os MM, Dengg R, Desisa SA, Desta A, Detkova D, Dewerchin M, Dieli CR, Dilloo D, Dimitriou F, Dinser J, Dipani N, Dirks J, Dittrich AM, Djermane L, Dogru Y, Dogu EF, Dombrowski A, Döring M, Drabe CH, Drerup S, Drexel B, Driessen GJ, Dückers G, Dudoit Y, Duppenthaler A, Durandy A, Ebetsberger-Dachs G, Ecser MB, David EJ, Eekman M, Ehl S, Ehrat R, Eisl E, Ekwall O, El Hawary R, Elbe S, Elcombe S, Eldash A, Eldeen YARS, El-Helou SM, Ellerbroek PM, Elling R, Elliott J, El-Marsafy A, Engelhardt A, Ernst D, Ersoy F, Esper S, Esteves I, Exley A, Faber M, Fabio G, Fahrni G, Faletti LE, Farber CM, Faria E, Farkas H, Farmaki E, Faßhauer M, Fasth A, Fätkenheuer G, Faustmann S, Fecker G, Feighery C, Feiterna-Sperling C, Fernandez-Cruz PE, Ferreira CC, Ferster A, Feuchtinger T, Feyen O, Finke D, Fischer A, Fitter S, Flaschberger S, Fleckenstein L, Föll D, Fontana A, Forino C, Förster-Waldl E, Franchet N, Freitag D, Frey UP, Friedel E, Friedrich W, Frisch B, Frischknecht L, Fritzemeyer S, Gagro A, Gahr M, Gambineri E, Gamper A, Gams F, Ganzow A, Garcez T, Garcia PM, Gardulf A, Garibay J, Garwer B, Gasteiger L, Gathmann B, Gathmann J, Gebauer C, Geberzahn L, Geikowski T, Geisen U, Gemander C, Gennery AR, Gerisch M, Gernert M, Gerrer K, Gerschmann S, Ghosh S, Giannini C, Gil HJ, Girndt M, Girrbach R, Girschick H, Gkantaras A, Gkougkourelas I, Gładysz D, Gnodtke E, Goda V, Goddard S, Goebel D, Goffard JC, Goldacker S, Gollowitsch EM, Gomes M, Gompels M, Gonzalez Granado LI, González M, Gordins P, Göschl L, Gossens L, Gößling K, Gowin E, Graafen L, Graca L, Graf D, Graf N, Grange E, Grashoff HA, Greil J, Grigoriadou S, Grimbacher B, Gronlund H, Groß-Wieltsch U, Guerra T, Guevara-Hoyer K, Guibert N, Gülnur B, Güngör T, Guseva M, Guzman D, H. 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NN, Vagedes D, Valicevic S, Vallelian F, van Beem RT, van Damme C, van de Ven A, van den Berg JM, van der Flier M, van Dissel JT, van Hagen PM, van Montfrans JM, van Ogtrop G, van Rens J, van Riel Christel AM, van Royen-Kerkhof A, van Well GTJ, Vasiliki A, Velbri S, Vencken J, Ventura A, Vermeulen F, Vermylen C, Viemann D, Viereck A, Villa A, Vincke J, Vinnemeier-Laubenthal L, Vo TKD, Vollbach K, Volokha A, von Bernuth H, von Bismarck P, Voss R, Voß S, Vural Y, Wachuga H, Wagner N, Wagström P, Wahle M, Wahn V, Wapp N, Warnatz K, Warneke M, Warris A, Wasmuth JC, Wasserfallen JB, Wawer A, Weber M, Weemaes CM, Weidinger S, Weiß M, Weißbarth-Riedel E, Werner A, Wessel S, Westkemper M, Wicher M, Wickmann L, Wiegert S, Wiehe M, Wiehler K, Wiesböck L, Wiesik-Szewczyk E, Williams A, Winkler B, Winkler C, Winkler M, Winkler M, Wintergerst U, Wisgrill L, de Witte J, Witte T, Wittkowski H, Wolf B, Wölke S, Wolschner C, Wolska-Kusnierz B, Wood P, Workman S, Worth A, Wortmann M, Wuillemin WA, Wulffraat NM, Wustrau K, Wyndham-Thomas C, Yegin O, Yildiran A, Yilmaz D, Young P, Yucel E, Zečević M, Erić Ž, Zepp F, Zetzsche K, Zeuner R, Zielen S, Zimmermann M (2024)
Publication Type: Journal article
Publication year: 2024
Book Volume: 96
Journal Issue: 6
DOI: 10.1002/jmv.29738
Immunocompromised individuals are at significantly elevated risk for severe courses of coronavirus disease 2019 (COVID-19). In addition to vaccination, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies (nAbs) have been applied throughout the pandemic, with time of treatment onset and potency against the currently prevailing virus variant identified as relevant factors for medical benefit. Using data from the European Society for Immunodeficiencies (ESID) registry, the present study evaluated COVID-19 cases in three groups of patients with inborn errors of immunity (IEI; 981 agammaglobulinemia patients on immunoglobulin replacement therapy (IGRT); 8960 non-agammaglobulinemia patients on IGRT; 14 428 patients without IGRT), and the neutralizing capacity of 1100 immunoglobulin lots against SARS-CoV-2 ("Wuhan" and Omicron strains), throughout 3 years. From the first (2020/2021) to the second (2021/2022) cold season, i.e., during the virus drift to the more contagious Omicron variants, an increase in case numbers was recorded that was comparable (~2- to 3-fold) for all three study groups. During the same period, immunoglobulin lots showed a profound nAb increase against the archetypal SARS-CoV-2 strain, yet only low levels of Omicron nAbs. Notably, shortly before the third (2022/2023) cold season, Omicron-neutralizing capacity of released immunoglobulin lots had plateaued at high levels. From the second to the third cold season, COVID-19 cases dropped markedly. While a ~6-fold case reduction was recorded for the groups of non-agammaglobulinemia patients on IGRT and IEI patients not receiving IGRT, the decline was ~30-fold for the group of agammaglobulinemia patients on IGRT. These findings suggest a substantial COVID-19-protective effect of IGRT, at least for distinct groups of antibody-deficient patients.
APA:
Karbiener, M., Kindle, G., Meyts, I., Seppänen, M.R., Candotti, F., Kamieniak, M.,... Zimmermann, M. (2024). Clinical efficacy of SARS-CoV-2 Omicron-neutralizing antibodies in immunoglobulin preparations for the treatment of agammaglobulinemia in patients with primary antibody deficiency. Journal of Medical Virology, 96(6). https://doi.org/10.1002/jmv.29738
MLA:
Karbiener, Michael, et al. "Clinical efficacy of SARS-CoV-2 Omicron-neutralizing antibodies in immunoglobulin preparations for the treatment of agammaglobulinemia in patients with primary antibody deficiency." Journal of Medical Virology 96.6 (2024).
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