Appel KS, Nürnberger C, Förster C, Polidori MC, Kohls M, Kraus T, Hettich-Damm N, Petersen J, Blaschke S, Bröhl I, Butzmann J, Dashti H, Deckert J, Dreher M, Fiedler K, Finke C, Geisler R, Hanses F, Hopff SM, Jensen BEO, Konik M, Lehnert K, de Miranda SM, Mitrov L, Miljukov O, Reese JP, Rohde G, Scherer M, Tausche K, Tebbe JJ, Vehreschild JJ, Voit F, Wagner P, Weigl M, Lemhöfer C, Witzenrath M, Schreiber S, Illig T, Hoffmann W, Heyder R, Heuschmann P, Herold S, Tamminga T, Lieb W, Krawczak M, Hermes A, Bahmer T, Schmidt S, Rönnefarth M, Krist L, Fricke J, Schaller J, Lorbeer R, Lorenz-Depiereux B, Kraus M, Weinert N, Schoneberg A, Rainers M, Pape C, Krefting D, Hanß S, Chaplinskaya I, Valentin H, Stahl D, Schattschneider M, Schaefer C, Nauck M, Bahls T, Jiru-Hillmann S, Schmidbauer L, Heuschmann PU, Fiessler C, Haug F, Haug J, Günther K, Wolf L, Weismantel C, Sikdar S, Schneider J, Hagen M, Stecher M, Seibel K, Schulze N, Sauer G, Lee C, Laugwitz M, Brechtel M, Prenzel R, Petersmann A, Meinhardt K, Meinhardt C, Kluge A, Juergens K, Hamprecht A, Guenther U, Griesinger F, Arlt A, Scheer C, Schaefer E, Piasta N, Doerr M, Becker K, Witzke O, Otte M, Madel RJ, Krawczyk A, Elsner C, Dolff S, Brochhagen L, Zeh S, Santibanez-Santana M, Nussbeck SY, Hermanns G, Hafke A, Torres Reyes C, Steinmann E, Schuette C, Schmidt WE, Reinacher-Schick A, Luecke T, Hellwig K, Gambichler T, Brueggemann Y, Brinkmann F, Schulze P, Schmidt J, Meybohm P, Liese J, Isberner N, Herrmann J, Haertel C, Haas K, Frey A, Frantz S, Trauner F, Struemper C, Rosenberger P, Malek N, Mahrhofer H, Kienzle K, Haeberle H, Göpel S, Bunk S, Bitzer M, Winter C, Spinner C, Mueller L, Michler T, Lieb J, Fricke L, Erber J, Barkey W, Schunk D, Rupp J, Plagge M, Pape D, Oberlaender M, Kujat C, Koerner M, Kaeding N, Friedrichs A, Cleef S, Wallner S, Schuster P, Niedermair T, Malfertheiner M, Hansch S, Haag O, Feustel M, Burkhardt R, Brochhausen-Delius C, Wipperfuerth J, Mueller-Wieland D, Marx N, Dahl E, Wilms C, Vollenberg R, Tepasse PR, Nowacki T, Meier JA, Boeckel G, Wirtz H, Mueller SD, Krug N, Bercker S, Baber R, Zeller T, Schlesner C, Petereit S, Kobbe R, Kluge S, Kerinn M, Jarczak D, Engels AL, Almahfoud M, Addo M, Vogl T, Vehreschild M, Klinsing S, Khodamoradi Y, Gruenewaldt A, Groh A, Cremer S, Bellinghausen C, Arendt C, Wolf K, Willam C, Vetter M, Schmid J, Prokosch HU, Neurath MF, Mang J, Leppkes M, Kremer AE, Kraska D, Timm J, Pereira JP, Paluschinski M, Lutterbeck M, Luedde T, Knopp L, Killer A, Keitel V, Feldt T, Bonin SV, Toepfner N, Spieth P, Seele K, Lindemann D, Koch T, Dressen S, Berner R, Altmann H, Roemmele C, Muzalyova A, Messmann H, Maerkl B, Langer A, Fuchs A, Engelmann M, Bader S, Silberbaur I, Laumerich B, Tessmer C, Dashti Y, Buechner N, Stellbrink C, Ruwe M, Muna A, Maasjosthusmann P, Kulamadayil-Heidenreich NS, Hornberg C, Heidenreich H, Hamelmann E, Alsaad K (2024)
Publication Type: Journal article
Publication year: 2024
Book Volume: 52
Pages Range: 1813-1829
Journal Issue: 5
DOI: 10.1007/s15010-024-02226-9
PURPOSE: The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. The aim of the study was to verify the functionality and correlates of a recently developed PCS score. METHODS: The PCS score was applied to the prospective, multi-center cross-sectoral cohort (in- and outpatients with SARS-CoV-2 infection) of the "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment and patient-reported outcome measure questionnaires were analyzed at 3 and 12 months (3/12MFU) after diagnosis. Scores indicative of PCS severity were compared and correlated to demographic and clinical characteristics as well as quality of life (QoL, EQ-5D-5L). RESULTS: Six hundred three patients (mean 54.0 years, 60.6% male, 82.0% hospitalized) were included. Among those, 35.7% (215) had no and 64.3% (388) had mild, moderate, or severe PCS. PCS severity groups differed considering sex and pre-existing respiratory diseases. 3MFU PCS worsened with clinical severity of acute infection (p = .011), and number of comorbidities (p = .004). PCS severity was associated with poor QoL at the 3MFU and 12MFU (p < .001). CONCLUSION: The PCS score correlated with patients' QoL and demonstrated to be instructive for clinical characterization and stratification across health care settings. Further studies should critically address the high prevalence, clinical relevance, and the role of comorbidities. TRAIL REGISTRATION NUMBER: The cohort is registered at www. CLINICALTRIALS: gov under NCT04768998.
APA:
Appel, K.S., Nürnberger, C., Förster, C., Polidori, M.C., Kohls, M., Kraus, T.,... Alsaad, K. (2024). Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON). Infection, 52(5), 1813-1829. https://doi.org/10.1007/s15010-024-02226-9
MLA:
Appel, Katharina S., et al. "Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON)." Infection 52.5 (2024): 1813-1829.
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