Network Biology Approaches in Ophthalmological Diseases: A Case Study of Glaucoma

Choudhari JK, Chatterjee T, Gupta S, Garcia-Garcia JG, Vera González J (2020)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2020

Publisher: Elsevier

Edited Volumes: Systems Medicine - Integrative, Qualitative and Computational Approaches

ISBN: 9780128160770

DOI: 10.1016/B978-0-12-801238-3.11586-7

Abstract

Glaucoma is an eye disease characterized by progressive damage to the optic nerve, often associated to high intraocular pressure, which causes vision impairment and vision loss in long term at the terminal phase. Glaucoma is a multifactorial disease because polymorphisms and deregulation of multiple genes are involved in the onset and development of the disease. However, deregulated genes do not act in isolation but are integrated into large networks of molecular entities. Systems and network biology are emerging disciplines in biomedicine in which mathematical modeling and computational biology tools are employed to integrate and analyze high-throughput quantitative biological data. In this article we discuss how these two new methodologies can be used to reconstruct the networks of deregulated genes behind glaucoma, networks that can be used to obtain mechanistic insights about the pathogenesis of the disease, and eventually to design molecular evidence-based therapies.

Authors with CRIS profile

Julio Vera González Professur für Tumorimmunologie (Schwerpunkt Systembiologie)

Involved external institutions

Raipur Institute of Technology IN India (IN) Universität Rostock DE Germany (DE) Universidad de Castilla-La Mancha (UCLM) ES Spain (ES)

How to cite

APA:

Choudhari, J.K., Chatterjee, T., Gupta, S., Garcia-Garcia, J.G., & Vera González, J. (2020). Network Biology Approaches in Ophthalmological Diseases: A Case Study of Glaucoma. In Olaf Wolkenhauer (Eds.), Systems Medicine - Integrative, Qualitative and Computational Approaches. Elsevier.

MLA:

Choudhari, Jyoti Kant, et al. "Network Biology Approaches in Ophthalmological Diseases: A Case Study of Glaucoma." Systems Medicine - Integrative, Qualitative and Computational Approaches. Ed. Olaf Wolkenhauer, Elsevier, 2020.

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