Stumpf C, Petzi S, Seybold K, Wasmeier G, Arnold M, Raaz D, Yilmaz A, Daniel W, Garlichs C (2009)
Publication Type: Journal article
Publication year: 2009
Book Volume: 116
Pages Range: 45-52
Journal Issue: 1
DOI: 10.1042/CS20080042
LV (left ventricular) remodelling is the basic mechanism of HF (heart failure) following MI (myocardial infarction). Although there is evidence that pro-inflammatory cytokines [including TNF-α (tumour necrosis factor-α) and IL-6 (interleukin-6)] are involved in the remodelling process, only little is known about the role of anti-inflammatory cytokines, such as IL-10. As accumulating evidence has revealed that statins possess anti-inflammatory properties, the aim of the present study was to elucidate the effect of atorvastatin on the modulation of the anti-inflammatory cytokine IL-10 and its effect on LV function in rats with HF subsequent to MI. Rats with MI, induced by permanent LAD (left anterior descending) branch coronary artery ligation, were treated for 4 weeks with atorvastatin (10 mg · kg-1 of body weight · day-1 via oral gavage) starting on the first day after induction of MI. Cardiac function was assessed by echocardiography and cardiac catheterization 4 weeks after MI induction. Membrane-bound and soluble fractions of TNF-α, IL-6 and IL-10 protein, the TNF-α/IL-10 ratio, serum levels of MCP-1 (monocyte chemoattractant protein-1) as well as myocardial macrophage infiltration were analysed. Treatment with atorvastatin significantly improved post-MI LV function (fractional shortening, + 120 %; dP/dtmax, + 147 %; and LV end-diastolic pressure, - 27 %). Furthermore atorvastatin treatment markedly decreased the levels of TNF-α, IL-6 and MCP-1, reduced myocardial infiltration of macrophages and significantly increased myocardial and serum levels of the anti-inflammatory cytokine IL-10. Thus the balance between pro-inflammatory and anti-inflammatory cytokines was shifted in the anti-inflammatory direction, as shown by a significantly decreased TNF-α/IL-10 ratio. Atorvastatin ameliorated early LV remodelling and improved LV function in rats with HF subsequent to MI. Our study suggests that the modulation of the balance between pro- and anti-inflammatory cytokines towards the anti-inflammatory cytokine IL-10 is one salutary mechanism underlying how atorvastatin influences post-MI remodelling and thus improves LV function. © The Authors Journal compilation © 2009 Biochemical Society.
APA:
Stumpf, C., Petzi, S., Seybold, K., Wasmeier, G., Arnold, M., Raaz, D.,... Garlichs, C. (2009). Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction. Clinical Science, 116(1), 45-52. https://doi.org/10.1042/CS20080042
MLA:
Stumpf, Christian, et al. "Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction." Clinical Science 116.1 (2009): 45-52.
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