Pediatric kidney transplantation in Europe, a clinical snapshot pilot

Oomen L, Bootsma-Robroeks CM, Bouts AH, Carbonell Pradas M, Gander R, Kienzl-Wagner K, König P, Pereira PL, Dunand O, Mosca SM, Pac M, Podracka L, Prytula AA, Sangermano M, Vitkevic R, Zieg J, van der Zanden LF, Feitz WF, de Wall LL

Publication Type: Journal article

Journal

Frontiers in Pediatrics Frontiers Media

Book Volume: 12

Article Number: 1432027

DOI: 10.3389/fped.2024.1432027

Abstract

Background: Pediatric kidney transplantations are rarely performed, and there is limited knowledge about the diversity in current clinical practices across Europe. This study aims to explore the utility of clinical snapshot studies in identifying these disparities, establishing a foundation for future snapshot studies and standardization efforts. Methods: A pilot clinical snapshot study was conducted, with invitations extended to all 109 pediatric kidney transplant centres in Europe. Each participating centre provided pre-, peri-, and postoperative data concerning their most recent thirty transplantations. The primary outcomes encompassed the evaluation of disparities in donor-recipient selection, surgical techniques, post-operative drainage procedures, and immunosuppressive therapy protocols. Secondary outcomes involved the analysis of rejection rates, incidence of infections, and graft survival. Results: The study involved 439 patients from fifteen centres (14%) in twelve countries, with varying transplant volumes (range 1–29 transplantations per year) and follow-up periods. Significant differences were found among centres in terms of donor types, cold and warm ischemia time, pre-emptive transplant rates, and kidney transplant drainage methods. The rate of living donors varied between 3% and 90% and the median duration of cold ischemia ranged was 770 min after deceased donation and 147 min after living donation. Basiliximab was the dominant induction therapy, yet steroid withdrawal varied widely. Infection, rejection, and graft survival rates also varied significantly between centres. Conclusion: This study revealed substantial variation in clinical practices among European centres performing pediatric kidney transplantations. These findings could serve as a stimulus for international dialogue and collaboration.

Authors with CRIS profile

Paul König Urologische Klinik

Involved external institutions

Azienda Ospedale Università Padova / University Hospital of Padova IT Italy (IT) Comenius University Bratislava SK Slovakia (SK) University Hospital Ghent BE Belgium (BE) Vilnius University / Vilniaus universitetas LT Lithuania (LT) Motol University Hospital / Fakultní nemocnice v Motole CZ Czech Republic (CZ) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) NL Netherlands (NL) Academic Medical Centre / Academisch Medisch Centrum (AMC) NL Netherlands (NL) Universitat de Barcelona (UB) / University of Barcelona ES Spain (ES) Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron ES Spain (ES) Medizinische Universität Innsbruck AT Austria (AT) Hospital Universitario La Paz ES Spain (ES) Centre Hospitalier Universitaire de La Réunion FR France (FR) Hospital Geral de Santo António PT Portugal (PT) Children's Memorial Health Institute / Instytut "Pomnik - Centrum Zdrowia Dziecka" PL Poland (PL)

How to cite

APA:

Oomen, L., Bootsma-Robroeks, C.M., Bouts, A.H., Carbonell Pradas, M., Gander, R., Kienzl-Wagner, K.,... de Wall, L.L. (2024). Pediatric kidney transplantation in Europe, a clinical snapshot pilot. Frontiers in Pediatrics, 12. https://doi.org/10.3389/fped.2024.1432027

MLA:

Oomen, Loes, et al. "Pediatric kidney transplantation in Europe, a clinical snapshot pilot." Frontiers in Pediatrics 12 (2024).

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