Clinical and pathological characterization of tebentafusp-associated skin toxicity: A cohort study with 33 patients
Tomsitz D, Kerl K, French LE, Heinzerling L (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 91
Pages Range: 1136-1142
Journal Issue: 6
DOI: 10.1016/j.jaad.2024.08.037
Abstract
Background: Tebentafusp is a novel treatment for patients with metastatic uveal melanoma and often causes cutaneous side effects. Objectives: The aim of this study was to better characterize these heterogenous cutaneous side effects. Methods: This prospective cohort study evaluated all patients from a tertiary hospital center who were treated with tebentafusp between January 2019 and June 2023 clinically and assessed skin biopsies histologically. Results: In total, 33 patients were analyzed. Skin toxicity was observed in 78.8% of patients and was classified into 5 clinical categories: (1) symmetrical erythematous patches (83.8%), (2) hemorrhagic macules (11.8%), (3) urticarial lesions (7.4%), (4) bullous lesions (1.5%), and (5) skin (8.5%) and hair depigmentation (11.4%). Histopathologic features were focal lymphocytic interface dermatitis with epidermal infiltration of CD8-positive lymphocytes. Patients with skin reactions had a significantly longer median overall survival compared to patients without any cutaneous events (34 versus 4 months, P <.001). Limitation: Monocentric study with a limited number of patients. Conclusion: Tebentafusp frequently induces cutaneous reactions. Pathogenesis is likely due to binding of tebentafusp to stimulated melanocytes in the skin, followed by infiltration and activation of lymphocytes. Development of treatment-induced skin reactions may be associated with survival benefits.
Involved external institutions
Germany (DE)How to cite
APA:
Tomsitz, D., Kerl, K., French, L.E., & Heinzerling, L. (2024). Clinical and pathological characterization of tebentafusp-associated skin toxicity: A cohort study with 33 patients. Journal of the American Academy of Dermatology, 91(6), 1136-1142. https://doi.org/10.1016/j.jaad.2024.08.037
MLA:
Tomsitz, Dirk, et al. "Clinical and pathological characterization of tebentafusp-associated skin toxicity: A cohort study with 33 patients." Journal of the American Academy of Dermatology 91.6 (2024): 1136-1142.
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