Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study)

Passoke S, Stern C, Häußler V, Kümpfel T, Havla J, Engels D, Jarius S, Wildemann B, Korporal-Kuhnke M, Senel M, Stellmann JP, Warnke C, Grothe M, Schülke R, Gingele S, Kretschmer JR, Klotz L, Walter A, Bergh FT, Aktas O, Ringelstein M, Ayzenberg I, Schwake C, Kleiter I, Sperber PS, Rust R, Schindler P, Bellmann-Strobl J, Paul F, Kopp B, Trebst C, Hümmert MW, Albrecht P, Angstwurm K, Asseyer S, Bayas A, Bednarz N, Behnke S, Berthele A, Bittner S, Bütow F, Buttmann M, Dawin E, Dersch R, Duchow A, Etgen T, Finke C, Fischer K, Förster M, Fousse M, Frank B, Freitag F, Gahlen A, Gass A, Gehrig J, Geis C, Giglhuber K, Goereci Y, Gold R, Gomes ABAGR, Graf J, Groppa S, Gutbrod J, Guthke K, Haarmann A, Hastermann M, Hellwig K, Hemmer B, Herfurth M, Herwerth M, Hoffmann F, Hoffmann O, Hofstadt-Van Oy U, Husseini L, Ingenhoven K, Junghans J, Kaste M, Kern K, Kern P, Kermer P, Kleinschnitz C, Köhler W, Körbel K, Kowarik M, Krämer M, Krumbholz M, Kunzmann V, Kurka N, Ladopoulos T, Landwehr A, Langel S, Lauenstein AS, Laurent S, Lee DH, Lehrieder D, Leypoldt F, Liebetrau M, Lindenblatt G, Linker R, Lohmann L, Lüdemann P, Luessi F, Maiworm M, Marziniak M, Mayer C, Meister S, Melms A, von Mering M, Metz I, Meuth S, Naumann J, Nenkov M, Neuhaus O, Neziraj T, Niederschweiberer M, Niehaus S, Oertel FC, Otto C, Pache F, Pakeerathan T, Paryjas S, Pawlitzki M, Pepping S, Pfeuffer S, Pompsch M, Pretzsch RA, Proebstel AK, Protopapa M, Puhlmann HU, Pul R, Rauer S, Rehfeldt T, Retzlaff N, Riedlinger A, Rommer P, Rostásy K, Rothhammer V, Rückriem L, Ruprecht K, Ruschil C, Saggau C, Schraad M, Schwab M, Schwarz P, Seipelt M, Sieb JP, Soloroza G, Sommer C, Stefanou A, Steinbrecher A, Stephanik H, Steuerwald V, Stoppe M, Stürner K, Süße M, Tarampanis A, Tauber S, Tkachenko D, Tsaktanis T, Tumani H, Wallwitz U, Walz A, Wandinger KP, Weber MS, Weise J, Wickel J, Wiendl H, Winkelmann A, Wohlrab F, Yalachkov Y, Zettl U, Ziemann U, Zipp F (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Article Number: jnnp-2024-333994

DOI: 10.1136/jnnp-2024-333994

Abstract

Background Data on cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are limited to studies with small sample sizes. Therefore, we aimed to analyse the extent, characteristics and the longitudinal course of potential cognitive deficits in patients with MOGAD. Methods The CogniMOG-Study is a prospective, longitudinal and multicentre observational study of 113 patients with MOGAD. Individual cognitive performance was assessed using the Paced Auditory Serial Addition Task (PASAT), the Symbol Digit Modalities Test (SDMT) and the Multiple Sclerosis Inventory Cognition (MuSIC), which are standardised against normative data from healthy controls. Cognitive performance was assessed at baseline and at 1-year and 2-year follow-up assessments. Multiple linear regression was used to analyse demographic and clinical predictors of cognitive deficits identified in previous correlation analyses. Results At baseline, the study sample of MOGAD patients showed impaired standardised performance on MuSIC semantic fluency (mean=-0.29, 95% CI (-0.47 to -0.12)) and MuSIC congruent speed (mean=-0.73, 95% CI (-1.23 to -0.23)). Around 1 in 10 patients showed deficits in two or more cognitive measures (11%). No decline in cognition was observed during the 1-year and 2-year follow-up period. Cerebral lesions were found to be negatively predictive for SDMT (B=-8.85, 95% CI (-13.57 to -4.14)) and MuSIC semantic fluency (B=-4.17, 95% CI (-6.10 to -2.25)) test performance. Conclusions Based on these data, we conclude that MOGAD patients show reduced visuomotor processing speed and semantic fluency to the extent that the disease burden includes cerebral lesions.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Essen Germany (DE) Universitätsklinikum Jena Germany (DE) Universitätsklinikum des Saarlandes (UKS) Germany (DE) Universitätsmedizin der Johannes Gutenberg-Universität Mainz Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universitätsklinikum Leipzig Germany (DE) Universitätsspital Basel Switzerland (CH) Klinikum Herford Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK e.V.) Germany (DE) Klinikum der Universität München (LMU Klinikum) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster Germany (DE) Universitätsklinikum Regensburg Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Kliniken Maria Hilf GmbH Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Knappschaftsklinikum Saar Germany (DE) Kliniken Südostbayern AG Germany (DE) Caritas-Krankenhaus Bad Mergentheim gemeinnützige GmbH Germany (DE) Universität Ulm Germany (DE) Universitätsmedizin Greifswald / Universitätsklinikum Greifswald Germany (DE) Universität Leipzig Germany (DE) Universitätsklinikum Köln Germany (DE) Katholisches Klinikum Bochum (St. Josef- und St. Elisabeth-Hospital gGmbH) Germany (DE) Immanuel Klinik Rüdersdorf Germany (DE) Städtisches Klinikum Görlitz Germany (DE) Klinikum Westfalen Germany (DE) Universitätsklinikum Münster Germany (DE) Klinikum Bremen-Nord Germany (DE) SRH Kliniken Landkreis Sigmaringen GmbH Germany (DE) Agaplesion Ev. Bathildiskrankenhaus Germany (DE) Nordwest-Krankenhaus Sanderbusch Germany (DE) Universitätsklinikum Tübingen Germany (DE) HELIOS Kliniken Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) Universitätsspital Zürich (USZ) Switzerland (CH) Technische Universität München (TUM) Germany (DE) Universitätsklinikum Göttingen Germany (DE) Asklepios Kliniken Germany (DE) Isar-Amper-Hospital Germany (DE) Schlosspark-Klinik Germany (DE) Universitätsklinikum Würzburg Germany (DE) Dietrich-Bonhoeffer-Klinikum Germany (DE) Universitätsklinikum Aachen (UKA) Germany (DE) Universitätsklinikum Ulm Germany (DE) Universitätsmedizin Rostock Germany (DE) Vestische Caritas-Kliniken GmbH Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) MediClin Hedon Klinik Germany (DE) Universitätsklinikum Magdeburg A.ö.R. Germany (DE) Alfried Krupp Krankenhaus Germany (DE) Katharinenhospital Stuttgart Germany (DE) Universitätsklinikum Mannheim / University Medical Centre Mannheim (Universitätsmedizin Mannheim) Germany (DE) Landeskrankenhaus (AöR) Germany (DE) Julius-Maximilians-Universität Würzburg Germany (DE) Universität Wien / University of Vienna Austria (AT) Klinikum Dortmund Germany (DE) Universitätsklinikum Freiburg Germany (DE) St. Josefs-Hospital Wiesbaden Germany (DE)

How to cite

APA:

Passoke, S., Stern, C., Häußler, V., Kümpfel, T., Havla, J., Engels, D.,... Zipp, F. (2024). Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study). Journal of Neurology Neurosurgery and Psychiatry. https://doi.org/10.1136/jnnp-2024-333994

MLA:

Passoke, Sarah, et al. "Cognition in patients with myelin oligodendrocyte glycoprotein antibody-associated disease: a prospective, longitudinal, multicentre study of 113 patients (CogniMOG-Study)." Journal of Neurology Neurosurgery and Psychiatry (2024).

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